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Reply to Auer

Leukemia volume 16, page 1397 (2002)Cite this article

The RARRES3 gene described in our study1 was originally assigned to the 11q23 region.2 Although some databases still place this gene at that location, further examination and analyses after completion of the human genome sequence reveal that the correct position of RARRES3 is at 11q12, as pointed out and documented by Dr Auer et al, in their letters to Leukemia.

 In spite of the new mapping of RARRES3 to 11q12, we observed a significant down-regulation of this gene in B-CLL patients including those with 11q23 deletions. As we discussed, RARRES3 may not be the targeted gene in these cases and other alterations including the existence of novel tumor suppressor genes have to be considered at this time.

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References

  1. Casanova B, de la Fuente MT, Garcia-Gila M, Sanz S, Silva JA, Garcia-Marco JA, Garcia-Pardo A . The class II tumor-suppressor gene RARRES3 is expressed in B cell lymphocytic leukemias and down-regulated with disease progression Leukemia 2001 15: 1521–1526

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  2. DiSepio D, Ghosn C, Eckert RL, Deucher A, Robinson N, Duvic M, Chandraratna RAS, Nagpal S . Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene Proc Natl Acad Sci USA 1998 95: 14811–14815

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  1. Centro de Investigaciones Biológicas, CSIC, Madrid, Spain

    A Garcia-Pardo

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Garcia-Pardo, A. Reply to Auer. Leukemia 16, 1397 (2002). https://doi.org/10.1038/sj.leu.2402508

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