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The clinical and biological dilemma of preleukemia presenting as aplastic anemia with chromosomal translocation t(4;11)

Leukemia volume 15, pages 866–867 (2001)Cite this article

The complex molecular events obligatory for initiation, latency and progression of malignancies is a subject of major research. Although nonrandom chromosomal translocations as well as other aberrations are considered to be of vast importance in the pathogenesis and diagnosis of malignancies, it seems that the exact role played by these molecular events is sometimes not clearly defined. Some chromosomal translocations such as t(14;18), t(2;5), and t(9;22) are typical for hematological malignancies but are also found in normal individuals. Other translocations, such as t(2;5), (8;14), (14;18) are not specific to a certain malignancy.1 There are no solid data regarding the occurrence of t(4;11) in normal individuals or in another malignancy than acute lymphatic leukemia.

We describe a patient who presented with pancytopenia after EBV infection with a consistent cytogenetic finding of translocation t(4;11) in recurrent bone marrow aspirations until he ultimately developed full blown acute leukemia 9 months later.

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Authors and Affiliations

  1. Department of Pediatric Hematology-Oncology, Danna Children Hospital, Tel-Aviv, Israel

    U Tabori, Y Burstein & R Dvir

  2. Department of Pediatric Hematology-Oncology, Sheba Medical Center, Tel-Hashomer, Israel

    U Tabori, G Rechavi & A Toren

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  1. U Tabori
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  2. Y Burstein
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  3. R Dvir
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  4. G Rechavi
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Tabori, U., Burstein, Y., Dvir, R. et al. The clinical and biological dilemma of preleukemia presenting as aplastic anemia with chromosomal translocation t(4;11). Leukemia 15, 866–867 (2001). https://doi.org/10.1038/sj.leu.2402102

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