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Prognosis in Childhood AML

Extramedullary infiltrates at diagnosis have no prognostic significance in children with acute myeloid leukaemia

Leukemia volume 15, pages 46–49 (2001)Cite this article

Abstract

This retrospective study was designed to review the relative frequency and prognostic significance of extramedullary infiltrates in children with acute myeloid leukaemia (AML). The registration data and initial discharge summaries were reviewed for all children diagnosed with AML, and registered by the Dutch Childhood Leukaemia Study Group (DCLSG). Between 1972 and 1998, 477 children were diagnosed with AML. Of these patients, 120 (25.1%) had extramedullary leukaemia (EML) at diagnosis. Four categories of EML were found: skin, soft tissue or bone, gingival infiltration and central nervous system (CNS) involvement. Patients who presented with gingival infiltrates, were older than those without EML or those in the other EML subgroups, had a high initial WBC count and a high proportion of M4/M5 morphological variants. This type of presentation could indicate a special biological entity. Univariate analysis of prognostic factors in patients treated after 1985 with intensive protocols showed that initial WBC count and the presence of favourable cytogenetic findings were significant. The presence of EML at diagnosis had no significant effect on event-free survival. In a stepwise multiple regression analysis only favourable cytogenetic findings remained significant.

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Acknowledgements

We are indebted to Dr C Uiterwaal and Mr P Westers for their advice on data collection and statistical analysis and to colleagues in the DCLSG for referring their patients. Members of the DCLSG Board are: Prof WA Kamps, Dr JPM Bökkerink, Dr ESJM de Bont, Dr JA Rammeloo, Dr H van den Berg, Dr B Granzen, Prof PM Hoogerbrugge, Dr R Pieters, Dr T Révész, Dr ETh Korthof, Prof AJP Veerman.

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Authors and Affiliations

  1. Department of Paediatric Haematology-Oncology, University Medical Centre, Utrecht, The Netherlands

    MM Bisschop, T Révész & M Bierings

  2. Dutch Childhood Leukaemia Study Group, The Hague, The Netherlands

    T Révész, JF van Weerden, ER van Wering, K Hählen & A van der Does-van den Berg

  3. University Medical Centre, Rotterdam, The Netherlands

    K Hählen

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Bisschop, M., Révész, T., Bierings, M. et al. Extramedullary infiltrates at diagnosis have no prognostic significance in children with acute myeloid leukaemia. Leukemia 15, 46–49 (2001). https://doi.org/10.1038/sj.leu.2401971

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