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Myeloma and Other Gammopathies

Deletions of chromosome 13q in monoclonal gammopathy of undetermined significance

Leukemia volume 14, pages 1975–1979 (2000)Cite this article

Abstract

Since deletion of chromosome 13q is a clinically relevant feature in multiple myeloma (MM), we analyzed bone marrow plasma cells from 29 patients with monoclonal gammopathy of undetermined significance (MGUS) to investigate the chromosome 13 status in MGUS. Studies were performed by interphase fluorescence in situ hybridization (FISH) with a panel of 13q14-specific probes (RB1, D13S319, D13S25, D13S31). Plasma cells with a deletion of at least one of the 13q14 loci were detected in 13 patients (44.8%) with MGUS. In five patients (17.2%), deletions of all four 13q14-specific probes were observed, and the additional deletion of a 13q telomeric region (D13S327) suggested loss of the entire 13q arm or monosomy 13. Loss of 13q14 was observed to be monoallelic and to occur in 11.0 to 35.0% of plasma cells (cut-off levels for a deletion <10% with all probes). Nine of 17 patients (52.9%) with MM progressing from a pre-existing MGUS had evidence for a deletion of 13q14 as determined by FISH with the RB1 probe. These results suggest that deletion of 13q14 is an early event in the development of monoclonal gammopathies, but its role for the eventual progression to MM remains to be determined prospectively.

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Acknowledgements

This work was supported by the Austrian ‘Fonds zur Förderung der wissenschaftlichen Forschung’ (Grant No. P12432-MED) and the ICP-Programme (Molecular Medicine) of the Austrian Ministry for Research and Transport.

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Authors and Affiliations

  1. First Department of Internal Medicine, Division of Clinical Oncology, University of Vienna, Vienna, Austria

    R Königsberg, J Ackermann, H Kaufmann, E Urbauer, S Schreiber, H Huber & J Drach

  2. Department of Internal Medicine I with Medical Oncology, Wilhelminenspital, Vienna, Austria

    N Zojer & H Ludwig

  3. Division of Hematology and Hemostaseology, University of Vienna, Vienna, Austria

    E Krömer & R Heinz

  4. Ludwig-Boltzmann-Institute for Hematology and Leukemia Research, Hanuschspital, Vienna, Austria

    U Jäger & H Gisslinger

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Königsberg, R., Ackermann, J., Kaufmann, H. et al. Deletions of chromosome 13q in monoclonal gammopathy of undetermined significance. Leukemia 14, 1975–1979 (2000). https://doi.org/10.1038/sj.leu.2401909

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