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Molecular Cytogenetics and Cytogenetics

Interstitial telomere repeats in translocations of hematopoietic disorders

Leukemia volume 14, pages 1630–1633 (2000)Cite this article

Abstract

Cytogenetic and fluorescence in situ hybridization studies have shown the presence of telomeric repeats in translocation present in three patients with hematopoietic malignancies. One had jumping translocations, involving 1q12 and 2q, 16p, and 19q. These sequences were detected by FISH only in derivative chromosomes t(1;16) and t(1;19) in the first patient, and t(1;7) in the second. They were not seen in derivative t(1;2) and t(7;8), respectively. Interstitial telomeric sequences were observed in der(2)t(1;2) in about half of the metaphases in the third patient. The instability of interstitial telomeric DNA repeats in translocations is shown by the present findings. Moreover it supports the hypothesis that the presence of intertitial telomere repeats is not sufficient to make it functional. Leukemia (2000) 14, 1630–1633.

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Acknowledgements

We sincerely acknowledge Mr A Londono for fruitful discussions.

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Authors and Affiliations

  1. Unité INSERM U 434, Paris, France

    M Busson Le Coniat & R Berger

  2. Laboratoire Central d’Hématologie, Hôpital La Milétrie, Poitiers, France

    F Brizard

  3. Laboratoire de Recherche en Cytogénétique Hémato-Cancérologique, Hôpital Saint Antoine, Paris, France

    NV Smadja

  4. Laboratoire d’Hématologie, Hôpital Saint Louis, Paris, France

    O Maarek

  5. Centre d’Etude du Polymorphisme Humain, Fondation Jean Dausset, Paris, France

    H Der Sarkissian

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  1. M Busson Le Coniat
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Busson Le Coniat, M., Brizard, F., Smadja, N. et al. Interstitial telomere repeats in translocations of hematopoietic disorders. Leukemia 14, 1630–1633 (2000). https://doi.org/10.1038/sj.leu.2401876

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