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Classification of APL

Hypergranular promyelocytic leukemia: correlation between morphology and chromosomal translocations including t(15;17) and t(11;17)

Leukemia volumeĀ 14,Ā pages 1197ā€“1200 (2000)Cite this article

Abstract

The FAB group has reviewed 32 cases of promyelocytic leukemia and variant forms. By utilizing published criteria the ability to make a correct diagnosis by morphology with molecular genetic confirmation and to eliminate cases that did not have the PML/RARĪ± rearrangement was excellent.

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Acknowledgements

This work was supported by grants from the National Cancer Institute, NIH, CA32102 (CLW), CA11083 (JMB). We are indebted to Dr Christopher Cox for statistical expertise and to Ms Sharon Doty for manuscript preparation.

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Author notes

  1. JM Bennett, D Catovsky, M-T Daniel, G Flandrin, DAG Galton and HR Gralnick: Members of the Frenchā€“Americanā€“British (FAB) Cooperative Group

Authors and Affiliations

  1. University of Rochester Cancer Center, Rochester, NY, USA

    JM Bennett

  2. Academic Department of Haematology and Cytogenetics, Royal Marsden Hospital, London, UK

    D Catovsky

  3. Institut de Recherches sur les Leucemies et les Maladies du Sang, Hopital Saint Louis, Paris, France

    M-T Daniel

  4. Service Central d'Hematologie, Groupe Hospitalier Necker- Enfants Malades, Paris, France

    G Flandrin

  5. MRC Leukemia Unit, Royal Postgraduate Medical School, London, UK

    DAG Galton

  6. Hematology Service, National Institutes of Health, Bethesda, MD, USA

    HR Gralnick

  7. University of New Mexico Cancer Center and Pathology Department, Albuquerque, NM, USA

    CL Willman

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  1. JM Bennett
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  2. D Catovsky
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  4. G Flandrin
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  5. DAG Galton
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  7. CL Willman
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Bennett, J., Catovsky, D., Daniel, MT. et al. Hypergranular promyelocytic leukemia: correlation between morphology and chromosomal translocations including t(15;17) and t(11;17). Leukemia 14, 1197ā€“1200 (2000). https://doi.org/10.1038/sj.leu.2401795

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