Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Methadone Induced Mortality as a Function of the Circadian Cycle

Nature volume 239, pages 397–398 (1972)Cite this article

An Erratum to this article was published on 22 December 1972

Abstract

METHADONE maintenance is an increasingly used approach in heroin addiction1,2. Because addicts are often provided with a number of days' supply of methadone for unsupervised use, problems of overdosage are becoming prevalent3–5. The effectiveness of many drugs is closely related to the circadian rhythm6–8, and it is important to evaluate methadone overdosage as a function of the circadian cycle.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Dole, V. P., J. Amer. Med. Assoc., 215, 1131 (1970).

    Article  Google Scholar 

  2. Kramer, J. C., Calif. Med., 113, 6 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Gardner, R., and Connell, P. H., Lancet, ii, 455 (1970).

    Article  Google Scholar 

  4. Gardner, R., J. Addict., 65, 113 (1970).

    Article  CAS  Google Scholar 

  5. Cranley, W. R., and Haddow, J. E., New Engl. J. Med., 284, 792 (1970).

    Google Scholar 

  6. Reinberg, A., and Halberg, F., Ann. Rev. Pharmacol., 11, 455 (1971).

    Article  CAS  Google Scholar 

  7. Pauly, J. E., and Scheving, L. E., Int. J. Neuropharmacol., 3, 651 (1964).

    Article  CAS  Google Scholar 

  8. Scheving, L. E., Vedral, D. F., and Pauly, J. E., Nature, 219, 621 (1968).

    Article  CAS  ADS  Google Scholar 

  9. Dole, V. P., and Nyswander, M. E., Brit. J. Addict. Alcohol., 63, 55 (1968).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry and Neurology, Walter Reed General Hospital, Washington DC, 20012

    ROBERT H. LENOX

  2. Behavioral Technology Consultants,

    THOMAS W. FRAZIER

Authors
  1. ROBERT H. LENOX
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. THOMAS W. FRAZIER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

LENOX, R., FRAZIER, T. Methadone Induced Mortality as a Function of the Circadian Cycle. Nature 239, 397–398 (1972). https://doi.org/10.1038/239397a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/239397a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing