Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Transformation of Mouse Cells infected with AKR Leukaemia Virus induced by Smog Extracts

Nature volume 239, pages 103–107 (1972)Cite this article

Abstract

A NUMBER of in vitro assay systems1–4, useful for chemical carcinogenesis studies, exploit the observation that preinfection of cells with “nontransforming” RNA tumour viruses lead not only to accelerated transformation but also to transformation not inducible by the carcinogens alone1.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Freeman, A. E., Price, P. J., Igel, H. J., Young, J. C., Maryak, J. M., and Huebner, R. J., J. Nat. Cancer Inst., 44, 65 (1970).

    CAS  PubMed  Google Scholar 

  2. Price, P. J., Freeman, A. E., Lane, W. T., and Huebner, R. J., Nature New Biology, 230, 144 (1970).

    Article  Google Scholar 

  3. Rhim, J. S., Vass, W., Cho, H. Y., and Huebner, R. J., Intern. J. Cancer, 7, 65 (1971).

    Article  CAS  Google Scholar 

  4. Rhim, J. S., Vass, W., Cho, H. Y., and Huebner, R. J., Proc. Amer. Assoc. Cancer Res., 12, 23 (1971).

    Google Scholar 

  5. Rhim, J. S., Creasy, B., and Huebner, R. J., Proc. US Nat. Acad. Sci., 68, 2212 (1971).

    Article  ADS  CAS  Google Scholar 

  6. Rhim, J. S., Creasy, B., Joglekar, M. H., Vass, W., and Huebner, R. J., Bact. Proc., 217 (1971).

  7. Rhim, J. S., Cho, H. Y., Joglekar, M. H., and Huebner, R. J., J. Nat. Cancer Inst. (in the press).

  8. Freeman, A. E., Price, P. J., Bryan, R. J., Gordon, R. J., Gilden, R. V., Kelloff, G. J., and Huebner, R. J., Proc. US Nat. Acad. Sci., 68, 445 (1971).

    Article  ADS  CAS  Google Scholar 

  9. Hartley, J. W., Rowe, W. P., Capps, W. I., and Huebner, R. J., Proc. US Nat. Acad. Sci., 53, 931 (1965).

    Article  ADS  CAS  Google Scholar 

  10. Huebner, R. J., Rowe, W. P., Turner, H. C., and Lane, W. T., Proc. US Nat. Acad. Sci., 50, 379 (1963).

    Article  ADS  CAS  Google Scholar 

  11. Passey, R. D., Brit. Med. J., 2, 1112 (1922).

    Google Scholar 

  12. Kennaway, E. L., J. Path. Bact., 27, 233 (1924).

    Article  CAS  Google Scholar 

  13. Leiter, J., Shimkin, M. B., and Shear, M. J., J. Nat. Cancer Inst., 3, 155 (1942).

    CAS  Google Scholar 

  14. Campbell, J. A., Brit. J. Exp. Path., 15, 287 (1934).

    CAS  Google Scholar 

  15. McDonald, S., Jr., and Woodhouse, D. L., J. Path. Bact., 54, 1 (1942).

    Article  Google Scholar 

  16. Kotin, P., Falk, H. L., Mader, P., and Thomas, M., AMA Arch. Ind. Health, 9, 153 (1954).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Microbiological Associates, Inc., Bethesda, Maryland, 20014

    J. S. RHIM, H. Y. CHO & L. RABSTEIN

  2. Department of Pathology, University of Southern California School of Medicine, Los Angeles, California, 90033

    R. J. GORDON, R. J. BRYAN & M. B. GARDNER

  3. Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20014

    R. J. HUEBNER

Authors
  1. J. S. RHIM
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Y. CHO
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. RABSTEIN
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. J. GORDON
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. J. BRYAN
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. B. GARDNER
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R. J. HUEBNER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

RHIM, J., CHO, H., RABSTEIN, L. et al. Transformation of Mouse Cells infected with AKR Leukaemia Virus induced by Smog Extracts. Nature 239, 103–107 (1972). https://doi.org/10.1038/239103a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/239103a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing