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Effect of Calcitonin on Vitamin D Metabolism

Abstract

VITAMIN D is converted by the liver to the major circulating form, 25-hydroxycholecalciferol (25-HCC)1, and further hydroxylated by the kidney2 to a more active metabolite, 1,25-dihydroxycholecalciferol (1,25-DHCC)3,4. The physiological mechanisms controlling this new renal endocrine function are still largely unknown, although both diet5 and parathyroid hormone6,7 have an influence. We report here experiments which show that calcitonin dramatically enhances production of 1,25-DHCC by the kidney. Our results have important physiological implications for understanding of calcium metabolism and may also have practical consequences in the choice of treatment for Paget's disease.

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GALANTE, L., COLSTON, K., MACAULEY, S. et al. Effect of Calcitonin on Vitamin D Metabolism. Nature 238, 271–273 (1972). https://doi.org/10.1038/238271a0

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