Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Survey of North American Science
  • Published:

Molecular Biology: Reverse Transcriptase, the DNA Polymerase of Oncogenic RNA Viruses

Nature volume 234, pages 194–198 (1971)Cite this article

The excitement aroused by the idea that transformation of cells by RNA tumour viruses might depend on the activity of a reverse transcriptase enzyme(s) specific to the virus has stimulated much research since the enzyme was discovered in 1970. But the questions of the physical identity and catalytic activities of the enzyme(s), its function in transformation and whether it is unique to RNA tumour viruses remain unanswered.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Temin, H. M., Virology, 23, 486 (1964).

    Article  CAS  PubMed  Google Scholar 

  2. Temin, H. M., Cancer Res., 28, 1835 (1968).

    CAS  PubMed  Google Scholar 

  3. Temin, H. M., and Mizutani, S., Nature, 226, 1211 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Baltimore, D., Nature, 226, 1209 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Temin, H. M., J. Nat. Cancer Inst. (editorial), 46, III (1971).

    Google Scholar 

  6. Temin, H. M., Persp. Biol. Med., 14, 11 (1970).

    Article  CAS  Google Scholar 

  7. Gallo, R. C., Blood (editorial) (in the press).

  8. Culliton, B. J., Science, 172, 9 (1971).

    Article  Google Scholar 

  9. Solomon, J., The Sciences, 2, 6 (1971).

    Article  Google Scholar 

  10. Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 227, 563 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 228, 430 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Schlom, J., Harter, D. H., Burny, A., and Spiegelman, S., Proc. US Nat. Acad. Sci., 68, 182 (1971).

    Article  ADS  CAS  Google Scholar 

  13. Temin, H. M., Virology, 23, 486 (1964).

    Article  CAS  PubMed  Google Scholar 

  14. Bader, J. P., Virology, 22, 462 (1964).

    Article  CAS  PubMed  Google Scholar 

  15. Baluda, M. B., and Nayak, D. P., J. Virol., 4, 554 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Temin, H. M., Cancer. Res., 28, 1835 (1968).

    CAS  PubMed  Google Scholar 

  17. Duesberg, P. H., Vogt, P. K., and Canaani, E., in Second Lepetit Colloquium on Biology and Medicine, The Biology of Oncogenic Viruses (edit. by Silvestri, L.) (North-Holland, Amsterdam, 1971).

    Google Scholar 

  18. Hanafusa, H., and Hanafusa, T., Virology, 43, 313 (1971).

    Article  CAS  PubMed  Google Scholar 

  19. Robinson, W. S., and Robinson, H. L., Virology, 44, 457 (1971).

    Article  CAS  PubMed  Google Scholar 

  20. Gurgo, D., Ray, R. K., Thiry, L., and Green, M., Nature, 229, 111 (1971).

    Article  CAS  Google Scholar 

  21. Gallo, R. C., Yang, S. S., and Ting, R. C., Nature, 228, 927 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  22. Gallo, R. C., Yang, S. S., Smith, R. G., Herrera, F., Ting, R. C., Bobrow, S. N., Davis, C., and Fujioka, S., in Second Lepetit Colloquium on Biology and Medicine, The Biology of Oncogenic Viruses (edit. by Silvestri, L.) (North-Holland, Amsterdam, 1971).

    Google Scholar 

  23. Yang, S. S., Smith, R. G., Ting, R. C., and Gallo, R. C., J. Nat. Cancer Inst. (in the press).

  24. Brockman, W. W., Carter, W., Li, L. H., Reusser, F., and Nichol, F. R., Nature, 230, 249 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  25. Carter, W. A., Brockman, W. W., and Borden, E. C., Nature New Biology, 232, 212 (1971).

    CAS  PubMed  Google Scholar 

  26. Parkman, R., Levy, J. A., and Ting, R. C., Science, 168, 387 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  27. Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 227, 563 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  28. Duesberg, P. H., and Canaani, E., Virology, 42, 783 (1970).

    Article  CAS  PubMed  Google Scholar 

  29. Mizutani, S., Boettiger, D., and Temin, H. M., Nature, 228, 424 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  30. Kacian, D. L., Watson, K. F., Burny, A., and Spiegelman, S., Biochim. Biophys. Acta, 246, 365 (1971).

    Article  CAS  PubMed  Google Scholar 

  31. Duesberg, P., Helm, K. V. D., and Canaani, E., Proc. US Nat. Acad. Sci., 68, 747 (1971).

    Article  ADS  CAS  Google Scholar 

  32. Ross, J., Scolnick, E. M., Todaro, G. J., and Aaronson, S. A., Nature New Biology, 231, 163 (1971).

    Article  CAS  PubMed  Google Scholar 

  33. Duesberg, P., Helm, K. V. D., and Canaani, E., Proc. US Nat. Acad. Sci., 68, 2505 (1971).

    Article  ADS  CAS  Google Scholar 

  34. Baltimore, D., and Smoler, D., Proc. US Nat. Acad. Sci., 68, 1507 (1971).

    Article  ADS  CAS  Google Scholar 

  35. Verma, I. M., Meuth, N. L., Bromfeld, E., Manly, K. F., and Baltimore, D., Nature New Biology, 233, 131 (1971).

    Article  CAS  PubMed  Google Scholar 

  36. Schlom, J., Spiegelman, S., and Moore, D., Nature, 231, 97 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  37. Priori, E. S., Dmochowski, L., Myers, B., and Wilbur, J. R., Nature New Biology, 232, 61 (1971).

    Article  CAS  PubMed  Google Scholar 

  38. Gallo, R., Sarin, P., Allen, P., Newton, B., Bowen, J., Priori, E. S., and Dmochowski, L., Nature New Biology, 232, 140 (1971).

    Article  CAS  PubMed  Google Scholar 

  39. Wade, N., Science, 173, 1220 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  40. Gerwin, B. I., Todaro, G., Zeve, V., Scolnick, E. M., and Aaronson, S. A., Nature, 228, 435 (1971).

    Article  ADS  Google Scholar 

  41. Fujinaga, K., Parsons, J. T., Beard, J. W., Beard, D., and Green, M., Proc. US Nat. Acad. Sci., 67, 1432 (1970).

    Article  ADS  CAS  Google Scholar 

  42. Spiegelman, S., Presented at the Second Colloquium on Biology and Medicine, Paris (1970).

  43. Goodman, N. C., and Spiegelman, S., Proc. US Nat. Acad. Sci., 68, 2203 (1971).

    Article  ADS  CAS  Google Scholar 

  44. Scolnick, E. M., Aaronson, S. A., Todaro, G. J., and Parks, W. P., Nature, 229, 318 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  45. Aaronson, S., Parks, W. P., Scolnick, E. M., and Todaro, G. J., Proc. US Nat. Acad. Sci., 68, 920 (1971).

    Article  ADS  CAS  Google Scholar 

  46. Scolnick, E. M., Presented at the Second International Congress of Virology, Budapest (1971).

  47. Todaro, G., in US National Academy of Science Symposium (in the press).

  48. Gallo, R. C., Yang, S. S., Smith, R. G., Herrera, F., Ting, R. C., and Fujioka, S., in Nucleic Acid-Protein Interactions and Nucleic Acid Synthesis in Viral Infection, Miami Winter Symposium (edit. by Ribbons, D. W., Woessner, J. F., and Schultz, J.) (North-Holland, Amsterdam, 1971).

    Google Scholar 

  49. Hirschman, S. Z., Science, 173, 441 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  50. Müller, W. E. G., Zahn, R. K., and Seidal, H. J., Nature New Biology, 232, 143 (1971).

    Article  PubMed  Google Scholar 

  51. Tuominen, F. W., and Kenney, F. T., Proc. US Nat. Acad. Sci., 68, 2198 (1971).

    Article  ADS  CAS  Google Scholar 

  52. Abrell, J., Smith, R. G., Robert, M., and Gallo, R. C. (unpublished results).

  53. Yang, S. S., Ting, R. C., and Gallo, R. C., Proc. Amer. Assoc. Cancer Res., 12, 36 (1971).

    Google Scholar 

  54. Spiegelman, S., Presented at the Miami Winter Symposium on Nucleic Acid-Protein Interactions and Nucleic Acid Synthesis in Viral Infection (1971).

  55. Lee-Huang, S., and Cavalieri, L. F., Proc. US Nat. Acad. Sci., 50, 1116 (1963).

    Article  ADS  CAS  Google Scholar 

  56. Kiessling, A. A., Weber, G. H., Deeney, A. O., Possehl, E. A., and Beaudreau, G. S., J. Virol., 7, 221 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

  57. Penner, P. E., Cohen, L. H., and Loeb, L. A., Nature New Biology, 232, 58 (1971).

    Article  CAS  PubMed  Google Scholar 

  58. Müller, W. E. G., Yamazaki, Z., Zahn, R. K., Brehm, G., and Korting, G., Biochem. Biophys. Res. Commun., 44, 433 (1971).

    Article  PubMed  Google Scholar 

  59. Penner, P. E., Cohen, L. H., and Loeb, L. A., Biochem. Biophys. Res. Commun., 42, 1228 (1971).

    Article  CAS  PubMed  Google Scholar 

  60. Cavalieri, L. F., and Carroll, E., Biochem. Biophys. Res. Commun., 41, 1055 (1971).

    Article  Google Scholar 

  61. Coffin, J., and Temin, H. M., J. Virol. (in the press).

  62. Ackermann, W. W., Murphy, W. H., Miller, B. A., Kurtz, H., and Barker, S. T., Biochem. Biophys. Res. Commun., 42, 723 (1971).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland, 20014

    ROBERT C. GALLO

Authors
  1. ROBERT C. GALLO
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

GALLO, R. Molecular Biology: Reverse Transcriptase, the DNA Polymerase of Oncogenic RNA Viruses. Nature 234, 194–198 (1971). https://doi.org/10.1038/234194a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/234194a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing