The excitement aroused by the idea that transformation of cells by RNA tumour viruses might depend on the activity of a reverse transcriptase enzyme(s) specific to the virus has stimulated much research since the enzyme was discovered in 1970. But the questions of the physical identity and catalytic activities of the enzyme(s), its function in transformation and whether it is unique to RNA tumour viruses remain unanswered.
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National Cancer Institute, Bethesda, Maryland 20014
- ROBERT C. GALLO
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