Abstract
WHEN the atomic model of oxyhaemoglobin had just been completed, we showed that the haemoglobin molecule is insensitive to replacements of most amino-acid residues on its surface but extremely sensitive to quite small alterations of internal non-polar contacts. And replacements near the haems and at the contacts between α and β subunits affect the respiratory function1.
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MORIMOTO, H., LEHMANN, H. & PERUTZ, M. Molecular Pathology of Human Haemoglobin: Stereochemical Interpretation of Abnormal Oxygen Affinities. Nature 232, 408–413 (1971). https://doi.org/10.1038/232408a0
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DOI: https://doi.org/10.1038/232408a0
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