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Estimation of Secondary Structure in Ribonucleic Acids

Nature volume 230, pages 362–367 (1971)Cite this article

Abstract

A simple method for estimating the secondary structure of an RNA molecule has been proposed on the basis of the knowledge of its sequence.

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References

  1. Zachau, H., Angew. Chem. Intern. Edit., 8, 711 (1969).

    Article  CAS  Google Scholar 

  2. Goodman, H. M., Billeter, M. A., Hindley, J., and Weissmann, C., Proc. US Nat. Acad. Sci., 67, 921 (1970).

    Article  ADS  CAS  Google Scholar 

  3. Adams, J. M., Jeppeson, P. G. N., Sanger, F., and Barrell, B. G., Nature, 223, 1009 (1969).

    Article  ADS  CAS  Google Scholar 

  4. Steitz, J. A., Nature, 224, 957 (1969).

    Article  ADS  CAS  Google Scholar 

  5. Hindley, J. L., and Staples, D. H., Nature, 224, 964 (1969).

    Article  ADS  CAS  Google Scholar 

  6. Billeter, M. A., Dahlberg, J. E., Goodman, H. M., Hindley, J., and Weissmann, C., Nature, 224, 1083 (1969).

    Article  ADS  CAS  Google Scholar 

  7. Nichols, J. L., Nature, 225, 147 (1970).

    Article  ADS  CAS  Google Scholar 

  8. Symp. No. 5, Nucleic Acid Structure, Eighth Intern. Cong. Biochem., 163 (1970).

  9. Brownlee, G. G., Sanger, F., and Barrell, B. G., Nature, 215, 735 (1967).

    Article  ADS  CAS  Google Scholar 

  10. Forget, B. G., and Weissman, S. M., Science, 158, 1695 (1967).

    Article  ADS  CAS  Google Scholar 

  11. Fellner, P., Ehresmann, C., and Ebel, J. P., Nature, 225, 26 (1970).

    Article  ADS  CAS  Google Scholar 

  12. Fresco, J. R., Alberts, B. M., and Doty, P., Nature, 188, 98 (1960).

    Article  ADS  CAS  Google Scholar 

  13. Fresco, J. R., Klotz, L. C., and Richards, E. G., Cold Spring Harbor Symp. Quant. Biol., 28, 83 (1963).

    Article  CAS  Google Scholar 

  14. Cotter, R. I., McPhie, P., and Gratzer, W. B., Nature, 216, 865 (1967).

    Article  ADS  Google Scholar 

  15. Cantor, C. R., Proc. US Nat. Acad. Sci., 59, 478 (1968).

    Article  ADS  CAS  Google Scholar 

  16. Thomas, jun., G. J., Biopolymers, 7, 325 (1969).

    Article  CAS  Google Scholar 

  17. Uhlenbeck, O. C., Baller, J., and Doty, P., Nature, 225, 508 (1970).

    Article  ADS  CAS  Google Scholar 

  18. Brostaff, S. W., and Ingram, V. M., Biochemistry, 9, 2372 (1970).

    Article  Google Scholar 

  19. Cramer, F., Doepner, H., van de Haar, F., Schlimme, E., and Seidel, H., Proc. US Nat. Acad. Sci., 61, 1348 (1968).

    Article  Google Scholar 

  20. Ofengand, J., J. Biol. Chem., 242, 5034 (1967).

    CAS  PubMed  Google Scholar 

  21. Levitt, M., Nature, 224, 759 (1969).

    Article  ADS  CAS  Google Scholar 

  22. Boedtker, H., and Kelling, D. G., Biochem. Biophys. Res. Commun., 29, 758 (1967).

    Article  CAS  Google Scholar 

  23. Raake, I. D., Biochem. Biophys. Res. Commun., 31, 528 (1968).

    Article  Google Scholar 

  24. Madison, J. T., Ann. Rev. Biochem., 37, 131 (1968).

    Article  CAS  Google Scholar 

  25. Cantor, C. R., Nature, 216, 513 (1967).

    Article  ADS  CAS  Google Scholar 

  26. Lewis, J., and Doty, P., Nature, 225, 510 (1970).

    Article  ADS  CAS  Google Scholar 

  27. Scheffler, I. E., Elson, E. L., and Baldwin, R. L., J. Mol. Biol., 48, 145 (1970).

    Article  CAS  Google Scholar 

  28. Kallenbach, N. R., J. Mol. Biol., 37, 445 (1968).

    Article  CAS  Google Scholar 

  29. Martin, F. H., Uhlenbeck, O. C., and Doty, P., J. Mol. Biol. (in the press).

  30. Uhlenbeck, O. C., Martin, F. H., and Doty, P., J. Mol. Biol. (in the press).

  31. Crothers, D. M., and Zimm, B. H., J. Mol. Biol., 9, 1 (1964).

    Article  CAS  Google Scholar 

  32. Steiner, R. F., J. Biol. Chem., 235, 2946 (1960).

    CAS  Google Scholar 

  33. Steiner, R. F., J. Biol. Chem., 236, 842 (1961).

    CAS  Google Scholar 

  34. Applequist, J., and Damle, V., J. Amer. Chem. Soc., 87, 1450 (1965).

    Article  CAS  Google Scholar 

  35. Krakauer, H., and Sturtevant, J. M., Biopolymers, 6, 491 (1968).

    Article  CAS  Google Scholar 

  36. Bunville, L. G., Geiduschek, E. P., Rawitscher, M. A., and Sturtevant, J. M., Biopolymers, 3, 213 (1965).

    Article  CAS  Google Scholar 

  37. Poland, D., and Scheraga, H. A., Theory of Helix-Coil Transitions in Biopolymers, 188 (Academic Press, New York, 1970).

    Google Scholar 

  38. Jacobson, H., and Stockmayer, W. H., J. Chem. Phys., 18, 1600 (1950).

    Article  ADS  CAS  Google Scholar 

  39. Fisher, M. E., J. Chem. Phys., 45, 1469 (1966).

    Article  ADS  CAS  Google Scholar 

  40. Crothers, D., Biopolymers, 6, 391 (1968).

    Google Scholar 

  41. Fresco, J. R., and Alberts, B. M., Proc. US Nat. Acad. Sci., 46, 311 (1960).

    Article  ADS  CAS  Google Scholar 

  42. Bautz, E. K. F., and Bautz, F. A., Proc. US Nat. Acad. Sci., 52, 1476 (1964).

    Article  ADS  CAS  Google Scholar 

  43. Ichikawa, T., Fujita, H., Matsuo, K., and Tsuboi, M., Bull. Chem. Soc. Japan, 40, 2272 (1967).

    Article  CAS  Google Scholar 

  44. Wintermeyer, W., Thiebe, R., Zachan, H. G., Riesner, D., Romer, R., and Maass, G., FEBS Lett., 5, 23 (1969).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, University of California, Berkeley, California, 94720

    IGNACIO TINOCO jun., OLKE C. UHLENBECK & MARK D. LEVINE

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  1. IGNACIO TINOCO jun.
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  2. OLKE C. UHLENBECK
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  3. MARK D. LEVINE
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TINOCO, I., UHLENBECK, O. & LEVINE, M. Estimation of Secondary Structure in Ribonucleic Acids. Nature 230, 362–367 (1971). https://doi.org/10.1038/230362a0

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