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Non-ferritin Iron Compound in Rat Small Intestinal Mucosa during Iron Absorption

Abstract

THE transfer of iron across the mucosal cells of the small intestine is an active metabolic process, and part of the iron taken up by the cells is rapidly delivered to the plasma while some of the remaining iron is deposited as ferritin1. A study of the subcellular distribution of orally administered 59Fe in rat intestinal mucosa has shown that the greater part is present in the soluble, non-particulate fraction, although 12–18 h after the oral dose there is some concentration of 59Fe in the mitochondria2. We have studied the iron compounds present during absorption by electrophoresis of the soluble fraction of the mucosal homogenate.

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WORWOOD, M., EDWARDS, A. & JACOBS, A. Non-ferritin Iron Compound in Rat Small Intestinal Mucosa during Iron Absorption. Nature 229, 409–410 (1971). https://doi.org/10.1038/229409b0

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