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Selective Inhibition of a Nuclear RNA Polymerase in Cells infected with Frog Virus

Nature volume 227, pages 294–295 (1970)Cite this article

Abstract

FROG virus (FV-3) is one of a group of polyhedral DNA-containing viruses, isolated from normal, tumour and diseased tissues of a variety of amphibia, which replicate within the cytoplasm of infected cells1. FV-3 multiplies at 12° to 31° C, with a distinctive cytopathic effect, in cell cultures from both poikilothermic and homothermic (including human) vertebrates1,2. The properties of the virion and the characteristics of virus replication have been reviewed by Granoff1. The earliest demonstrable ovent in cells infected by FV-3 is a marked depression of cellular RNA synthesis, within 1 h of infection1,3.

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Authors and Affiliations

  1. Seconda Cattedra di Microbiologia,

    F. COSTANZO, M. LA PLACA & ANNA MANNINI PALENZONA

  2. Istituto di Patologia generale, Università di Bologna, 40126, Bologna, Italy

    F. NOVELLO & F. STIRPE

Authors
  1. F. COSTANZO
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  2. M. LA PLACA
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  3. ANNA MANNINI PALENZONA
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  4. F. NOVELLO
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  5. F. STIRPE
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COSTANZO, F., LA PLACA, M., MANNINI PALENZONA, A. et al. Selective Inhibition of a Nuclear RNA Polymerase in Cells infected with Frog Virus. Nature 227, 294–295 (1970). https://doi.org/10.1038/227294a0

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