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Accumulation of Chorio-retinotoxic Drugs in the Foetal Eye

Nature volume 227, pages 12571258 (19 September 1970) | Download Citation

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Abstract

USING whole body autoradiography1 we have found a selective accumulation and retention of certain drugs-in the eyes of mouse foetuses. These drugs are known to cause ocular damage in adult humans and experimental animals. The injury (toxic retinopathy), which is not seen in albino animals, has been related to the affinity of the drugs for the melanin structures of the eye2. The risk of foetal ocular damage appears to have been neglected in the past.

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Author information

Affiliations

  1. Department of Toxicology, University of Uppsala, Uppsala, Sweden.

    • S. ULLBERG
    • , N. G. LINDQUIST
    •  & S. E. SJÖSTRAND

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https://doi.org/10.1038/2271257a0

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