Abstract
IN the course of investigations on the immunogenic hypothesis of multiple sclerosis we have attempted the preparation of a “chemically pure myelin” and come to the conclusion that the giant molecular complex which composes the structure which the morphologist identifies as myelin has a certain integral molecular component which displays such a differentially high order of instability that this may be of great biological significance. A specific protein material is released rapidly post mortem from the intraperiod line of myelin and also from ultracentrifugally purified myelin in vitro, in conditions which make enzyme mediation improbable, and the myelin so obtained has a characteristic structure which we term “collapsed myelin”. Little else besides this protein seems to be released; and this protein has been shown to be a single entity identical with the “basic encephalitogenic protein” of central nervous tissue1–3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Roboz-Einstein, E., Robertson, D. M., DiCaprio, J. M., and Moore, W., J. Neurochem., 9, 353 (1962).
Kies, M. W., and Alvord, E. C., in Allergic Encephalomyelitis (edit. by Kies, M. W., and Alvord, E. C.) (Thomas, Springfield, 1959).
Lumsden, C. E., Robertson, D. M., and Blight, R., J. Neurochem., 13, 127 (1966).
Autilio, L. A., Norton, W. T., and Terry, R. D., J. Neurochem., 11, 17 (1964).
Fernández-Morán, H., and Finean, J. B., J. Biophys. Biochem. Cytol., 3, 725 (1957).
Finean, J. B., in Electron Microscopy in Anatomy (Anatomical Society Symposium on the Ultrastructure of Cells) (London, Arnold, 1961).
Wetlaufer, D. B., Adv. Protein Chem., 17, 303 (1962).
Eylar, E. H., Salk, J., Beveridge, G. C., and Brown, L. V., Arch. Biochem. Biophys., 132, 34 (1969).
Hashim, G. H., and Eylar, E. H., Arch. Biochem. Biophys., 135, 324 (1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DICKINSON, J., JONES, K., APARICIO, S. et al. Localization of Encephalitogenic Basic Protein in the Intraperiod Line of Lamellar Myelin. Nature 227, 1133–1134 (1970). https://doi.org/10.1038/2271133a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2271133a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.