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Total Synthesis of the Gene for an Alanine Transfer Ribonucleic Acid from Yeast       

Nature 227, 27–34 (04 July 1970) | Download Citation

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Abstract

By exploiting the natural ability of polynucleotides to align by base pairing and using polynucleotide kinase and ligase, chemically synthesized segments have been combined into a double stranded DNA corresponding to the gene for the earliest characterized tRNA.

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Affiliations

  1. Institute for Enzyme Research, University of Wisconsin, Madison, Wisconsin 53706

    • K. L. AGARWAL
    • , H. BÜCHI
    • , M. H. CARUTHERS
    • , N. GUPTA
    • , H. G. KHORANA
    • , K. KLEPPE
    • , A. KUMAR
    • , E. OHTSUKA
    • , U. L. RAJBHANDARY
    • , J. H. VAN DE SANDE
    • , V. SGARAMELLA
    • , H. WEBER
    •  & T. YAMADA       

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https://doi.org/10.1038/227027a0

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