Abstract
The actions of the cardiac glycosides are antagonized by K+. This results from a reduction in the rate of combination of glycoside with its receptors.
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References
Schatzmann, H. J., Helv. Physiol. Acta, 11, 346 (1953).
Glynn, I. M., Pharmacol, Rev., 16, 381 (1964).
Hoffman, J. F., Amer. J. Med., 41, 666 (1966).
Girardi, A. J., Warren, J., Goldman, C., and Jefferies, B., Proc. Soc. Exp. Biol. Med., 98, 18 (1958).
Baker, P. F., and Willis, J. S., Biochim. Biophys. Acta, 183, 646 (1969).
Whittam, R., and Ager, M. E., Biochem. J., 93, 337 (1964).
Baker, P. F., and Connelly, C. M., J. Physiol., 185, 270 (1966).
Garrahan, P. J., and Glynn, I. M., J. Physiol., 192, 175 (1967).
Baker, P. F., Blaustein, M. P., Keynes, R. D., Manil, J., Shaw, T. I., and Steinhardt, R. A., J. Physiol., 200, 459 (1969).
Sjodin, R. A., and Beauge, L. A., J. Gen. Physiol., 51, 152s (1968).
Schwartz, A., Matsui, H., and Laughter, A. H., Science, 159, 323 (1968).
Albers, R. W., Koval, G. J., and Siegel, G. J., Mol. Pharmacol., 4, 324 (1968).
Baker, P. F., and Manil, J., Biochim. Biophys. Acta, 150, 328 (1968).
O'Donnell, J. M., and Ellory, J. C., Biochem. J. (in the press).
Glynn, I. M., J. Physiol., 136, 148 (1957).
Schatzmann, H. J., Biochim. Biophys. Acta, 94, 89 (1965).
Matsui, H., and Schwartz, A., Biochim. Biophys. Acta, 128, 380 (1966).
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BAKER, P., WILLIS, J. Potassium Ions and the Binding of Cardiac Glycosides to Mammalian Cells. Nature 226, 521–523 (1970). https://doi.org/10.1038/226521a0
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DOI: https://doi.org/10.1038/226521a0
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