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Induction of Immunity and Tolerance in vitro in the Absence of Phagocytic Cells

Abstract

IN previous reports on the induction of immunological tolerance in vitro1,2 we presented evidence suggesting that specific unresponsiveness is mediated by the direct encounter of antigen molecules with immunocompetent cells. The kinetics of the antigen-dose response in vitro1,2 to H-antigens of Salmonella adelaide (polymerized flagellin, POL)3 suggested that in this antigen system not only tolerance, but also immunity, may result from such direct interaction. This assumption, however, contradicts certain current concepts which regard the macrophage as an essential participant in the induction of humoral immunity to all antigens. In this report, we will describe experiments which help to elucidate some aspects of this situation.

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DIENER, E., SHORTMAN, K. & RUSSELL, P. Induction of Immunity and Tolerance in vitro in the Absence of Phagocytic Cells. Nature 225, 731–732 (1970). https://doi.org/10.1038/225731a0

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