Abstract
Tuffrey, Bishun and Barnes recently reported the presence of large numbers of cells of maternal origin in the bone marrow and other tissues of mice derived from fertilized ova transplanted into the uterus of a recipient female1. In their investigation inbred white CFW mice were used as donors of 3.5 day blastocysts transferred to the uterus of agouti CBA/H-T6T6 females 2.5 days post coitum. Of the eight uterine-nurtured CFW mice obtained by this method and examined between 4 and 60 days after birth, seven were reported to have the short T6 marker chromosomes characteristic of the mother's cells in up to 33 per cent of mitoses. This surprising finding, with its considerable biological implications, stimulated us to seek to confirm and extend the work.
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References
Tuffrey, M., Bishun, N. P., and Barnes, R. D., Nature, 221, 1029 (1969).
Kirby, D. R. S., J. Embryol. Exp. Morphol., 10, 496 (1962).
Ford, C. E., in Tissue Grafting and Radiation (Academic Press, NY, 1966).
Uphoff, D. E., and Deringer, M. K., Coll. Intern. du Centre Nat. Rech. Scientifique, No. 147, 245 (1965).
Billingham, R. E., Palm, J., and Silvers, W. K., Science, 147, 514 (1965).
Jones, E. C., and Krohn, P. L., Nature, 195, 1064 (1962).
Lengerova, A., Folia Biol., 3, 333 (1957).
Nathan, P., Gonzalez, E., and Miller, B. F., Nature, 188, 77 (1960).
Najarian, J. S., and Dixon, F. J., Proc. Soc. Exp. Biol. and Med., 112, 136 (1963).
Tai, C., and Halasz, N. A., Science, 158, 125 (1967).
Matosic, M., Keckes, S., and Allegretti, N., Nature, 216, 371 (1967).
Finegold, M., and Michie, D., J. Embryol. Exp. Morphol., 9, 618 (1961).
Peer, L. A., Bernhard, N., and Walker, J. C., Amer. J. Surg., 95, 239 (1958).
Taylor, A. I., and Polani, P. E., Lancet, i, 1226 (1965).
Kadowaki, J. I., Thompson, R. I., Zuelzer, W. W., Woolley, P. V., Brough, A. J., and Gruber, D., Lancet, ii, 1152 (1965).
diGeorge, A. M., in Birth Defects—Immunologic Deficiency Diseases in Man, 4, No. 1 (National Foundation, 1968).
El-Alfi, O. S., and Hathout, H., Amer. J. Obstet. Gynec., 103, 599 (1969).
Naeslund, J., Acta. Obstet. Gynec. Scand., 30, 231 (1951); Mengert, W. F., Rights, C. S., Bates, C. R., Reid, A. F., Wolf, G. R., and Nabors, G. C., Amer. J. Gynec. Obstet., 69, 678 (1955); Macris, N. T., Hellman, L. M., and Watson, R. J., Amer. J. Gynec. Obstet., 76, 1214 (1958); Desai, R. G., and Creger, W. P., Blood, 21, 665 (1963).
Cohen, F., Zuelzer, W. W., Gustafson, D. C., and Evans, M. M., Blood, 23, 621 (1964); McConnell, R. B., Ann. Rev. Med., 17, 291 (1966).
Walknowska, J., Conte, F. A., and Grumbach, M. M., Lancet, i, 1119 (1969).
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BILLINGTON, W., KIRBY, D., OWEN, J. et al. Placental Barrier to Maternal Cells. Nature 224, 704–706 (1969). https://doi.org/10.1038/224704a0
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DOI: https://doi.org/10.1038/224704a0
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