Abstract
ALTERATIONS in the intracellular concentration of cyclic 3′,5′-AMP have been implicated in the action of many hormones and pharmacological agents in a variety of tissues1. In many cases, drugs, the action of which in liver, myocardium, adrenal and other tissues has been attributed to their effects on cyclic AMP concentrations, are known to influence aggregation of blood platelets, for example, platelet aggregation is inhibited by methyl xanthines2 and reserpine3, which inhibit cyclic nucleotide phosphodiesterase4,5, and is augmented by epinephrine6, which stimulates adenyl cyclase in liver, fat cells and myocardium7. 5-Hydroxytryptamine induces platelet aggregation8; it stimulates adenyl cyclase in the liver fluke9. Prostaglandin PGE1 is a potent inhibitor of platelet clumping10; it increases the level of cyclic AMP in adipose tissue11 but in some circumstances may lower its concentration in isolated fat cells1.
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Affiliations
Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts.
- EDWIN W. SALZMAN
- & LENA L. NERI
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