Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Induction of Immunological Tolerance by Porcine Liver Allografts

Nature volume 223, pages 472–476 (1969)Cite this article

Abstract

Liver allografting experiments with pigs show that animals given no immunosuppression will survive for prolonged periods with orthotopic liver transplants. Similar animals can reject skin, kidneys and hearts rapidly. Orthotopic and accessory heterotopic liver allografts protect preferentially from rejection grafts of donor specific skin, kidney and possibly heart. Injected soluble liver antigen may also protect donor specific tissue from rejection. It is suggested that allogeneic liver can induce immunological tolerance in immunologically mature pigs.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Moore, F. D., Brownell Wheeler, H., Demissianos, H. V., Smith, L. L., Balunkura, O., Abel, K., Greenberg, J. B., and Dammin, G. J., Ann. Surg., 152, 374 (1960).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Starzl, T. E., Kaupp, H. A., Brock, D. R., Linmann, J., and Moss, W. T., Trans. Proc., 58, 131 (1965).

    Google Scholar 

  3. Lee, S., and Edgington, T. E., Amer. J. Path., 52, 649 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Starzl, T. E., Groth, C. G., Brettschneider, L., Penn, I., Fulginiti, V. A., Moon, J. B., Blanchard, H., Martin, jun., A. H., and Porter, K. A., Ann. Surg., 168, 392 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Calne, R. Y., Williams, R., Dawson, J. L., Ansell, I. D., Evans, D. B., Flute, P. T., Herbertson, B. M., Johsey, V., Keates, G. H. W., Knill-Jones, R. P., Mason, S. A., Millard, P. R., Pena, J. R., Pentlow, B. D., Salaman, J. R., Sells, R. A., and Cullum, P. A., Brit. Med., J., 4, 541 (1968).

    CAS  Google Scholar 

  6. Peacock, J. H., and Terblanche, J., The Liver, 333 (Butterworths, London, 1967).

    Google Scholar 

  7. Calne, R. Y., White, H. J. O., Yoffa, D. E., Maginn, R. R., Binns, R. M., Samuel, J. R., and Molina, V. P., Brit. Med. J., 2, 478 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Terblanche, J., Peacock, J. H., Hobbs, K. E. F., Hunt, A. C., Bowes, J., Tierris, E. J., Palmer, D. B., and Blecher, T. E., SA Med. J., 42, 486 (1968).

    CAS  Google Scholar 

  9. Mieny, C. J., SA Med. J., 42, 670 (1968).

    CAS  Google Scholar 

  10. Binns, R. M., Nature, 214, 179 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Calne, R. Y., White, H. J. O., Yoffa, D. E., Binns, R. M., Maginn, R. R., Herbertson, B. M., Millard, P. R., Molina, V. P., and Davis, D. R., Brit. Med. J., 4, 645 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Calne, R. Y., White, H. J. O., Binns, R. M., Herbertson, B. M., Millard, P. R., Pena, J. R., Salaman, J. R., Samuel, J. R., and Davis, D. R., Trans. Proc., 1, 321 (1969).

    CAS  Google Scholar 

  13. Calne, R. Y., Yoffa, D. E., White, H. J. O., and Maginn, R. R., Brit. J. Surg., 55, 203 (1968).

    Article  CAS  PubMed  Google Scholar 

  14. Calne, R. Y., Ann. Roy. Coll. Surg., 42, 283 (1968).

    CAS  Google Scholar 

  15. Binns, R. M., thesis, Univ. Cambridge (1968).

  16. Bengoechea-Gonzalez, E., Awane, Y., and Reemtsma, K., Arch. Surg., 94, 1 (1967).

    Article  CAS  PubMed  Google Scholar 

  17. Mann, F. C., Priestley, J. T., Markowitz, J., and Yater, W. M., Arch. Surg., 26, 219 (1933).

    Article  Google Scholar 

  18. Davies, D. A. L., Immunology, 11, 115 (1966).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Nathenson, S. G., and Davies, D. A. L., Proc. US Nat. Acad. Sci., 56, 476 (1966).

    Article  ADS  CAS  Google Scholar 

  20. Davies, D. A. L., Transplantation, 5, 31 (1967).

    Article  CAS  Google Scholar 

  21. Davies, D. A. L., Manstone, A. J., Viza, D. C., Colombani, J., and Dausset, J., Transplantation, 6, 571 (1968).

    Article  CAS  PubMed  Google Scholar 

  22. Sheil, A. G. R., Mitchell, R. M., Dammin, G. J., and Murray, J. E., Advance in Transplantation, 599 (Munksgaard, Copenhagen, 1967).

    Google Scholar 

  23. Stuart, F. P., Saitoh, T., Fitch, and Spargo, B. H., Surgery, 64, 17 (1968).

    CAS  PubMed  Google Scholar 

  24. Mandel, M. A., Monaco, A. P., and Russell, P. S., J. Immunol., 95, 673 (1965).

    CAS  PubMed  Google Scholar 

  25. Hilgert, I., and Kristofova, H., Transplantation, 5, 1256 (1967).

    Article  CAS  PubMed  Google Scholar 

  26. Palm, J., and Manson, L. A., Transplantation, 6, 666 (1968).

    Article  Google Scholar 

  27. Hunt, A. C., Brit. J. Exp. Path., 49, 338 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Binns, R. M., and Hall, J. G., Brit. J. Exp. Path., 47, 275 (1966).

    PubMed Central  Google Scholar 

  29. Kelly, W. D., McKneally, M. S., Oliveras, S., Martinez, C., and Good, R. A., Transplantation, 4, 489 (1966).

    Article  CAS  PubMed  Google Scholar 

  30. Wilson, D. B., Silvers, W. K., and Nowell, P. C., J. Exp. Med., 126, 655 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, University of Cambridge,

    R. Y. CALNE, R. A. SELLS, J. R. PENA & D. R. DAVIS

  2. Department of Pathology, University of Cambridge,

    P. R. MILLARD & B. M. HERBERTSON

  3. The Department of Experimental Pathology, A. R. C. Institute of Animal Physiology, Babraham

    R. M. BINNS

  4. Searle Research Laboratories, High Wycombe

    D. A. L. DAVIES

Authors
  1. R. Y. CALNE
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. A. SELLS
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. R. PENA
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. R. DAVIS
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. R. MILLARD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. B. M. HERBERTSON
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R. M. BINNS
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. D. A. L. DAVIES
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

CALNE, R., SELLS, R., PENA, J. et al. Induction of Immunological Tolerance by Porcine Liver Allografts. Nature 223, 472–476 (1969). https://doi.org/10.1038/223472a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/223472a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing