Abstract
HUMAN platelets contain large amounts of adenine nucleotides1 of which an unusually high proportion is in the form of ADP2–7. The ratio of ATP to ADP in human platelets is about 2 compared with a value of 9 in red cells8 and 11 in muscle9. Incorporation of radioactive precursors into platelet nucleotides and the selective retention of labelled nucleotides in the platelet during nucleotide release induced by thrombin or collagen4,10 have demonstrated that the bulk of the ADP in human platelets is metabolically inert and that it is the inert fraction which is released.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Born, G. V. R., Biochem. J., 68, 695 (1958).
Holmsen, H., in Biochemistry of Blood Platelets (edit. by Kowalski, E., and Niewiarowski, S.), 81 (Academic Press, London, 1967).
Haslam, R. J., in Physiology of Hemostasis and Thrombosis (edit. by Johnson, S. A., and Seegers, W. H.), 88 (Thomas, Springfield, Ill., 1967).
Ireland, D. M., Biochem. J., 105, 857 (1967).
Mills, D. C. B., Robb, I. A., and Roberts, G. C. K., J. Physiol., 195, 715 (1968).
Loder, P. B., Hirsch, J., and DeGruchy, G. C., Brit. J. Haemat., 14, 563 (1968).
Karpatkin, S., and Langer, R. M., J. Clin. Invest., 47, 2158 (1968).
Bishop, C., Ranklin, D. M., and Talbot, J. H., J. Biol. Chem., 234, 1233 (1959).
Bendall, J. R., and Davey, C. L., Biochim. Biophys. Acta, 26, 93 (1957).
Holmsen, H., Scand. J. Clin. Lab. Invest., 17, 239 (1965).
Mills, D. C. B., and Roberts, G. C. K., Nature, 213, 35 (1967).
Bergmeyer, H. U., Methods of Enzymatic Analysis (Academic Press, London, 1963).
Holmsen, H., Holmsen, I., and Bernhardson, A., Analyt. Biochem., 17, 456 (1966).
Humphrey, H. J., and Jaques, R., J. Physiol., 124, 305 (1954).
Goldstein, A., Biostatistics (Macmillan, New York, 1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MILLS, D., THOMAS, D. Blood Platelet Nucleotides in Man and Other Species. Nature 222, 991–992 (1969). https://doi.org/10.1038/222991a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/222991a0
This article is cited by
-
Intracellular adenosine triphosphate as a measure of human tumor cell viability and drug modulated growth
In Vitro Cellular & Developmental Biology (1987)
-
ATP content in platelets at various stages of ontogeny
Bulletin of Experimental Biology and Medicine (1975)
-
Changes in the Adenylate Energy Charge in Human Blood Platelets induced by Adenosine Diphosphate
Nature New Biology (1973)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.