Abstract
HUMAN platelets contain large amounts of adenine nucleotides1 of which an unusually high proportion is in the form of ADP2–7. The ratio of ATP to ADP in human platelets is about 2 compared with a value of 9 in red cells8 and 11 in muscle9. Incorporation of radioactive precursors into platelet nucleotides and the selective retention of labelled nucleotides in the platelet during nucleotide release induced by thrombin or collagen4,10 have demonstrated that the bulk of the ADP in human platelets is metabolically inert and that it is the inert fraction which is released.
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Affiliations
MRC Thrombosis Research Group, Department of Pharmacology, Royal College of Surgeons, Lincoln's Inn Fields, London WC2.
- D. C. B. MILLS
Vascular Laboratory, Lemuel Shattuck Hospital and Tufts University School of Medicine, Boston, Massachusetts, USA.
- D. P. THOMAS
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