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Subacute Sclerosing Panencephalitis: Structures resembling Myxovirus Nucleocapsids in Cells cultured from Brains

Nature volume 222, pages 888–890 (1969)Cite this article

Abstract

DURING the past 2 yr, reports from several laboratories1–3 have associated subacute sclerosing panencephalitis (SSPE) with measles on the basis of three observations in patients with this disease: (1) an unusually high level of anti-measles antibody in their serum and spinal fluid; (2) the demonstration in brain sections of measles antigen by means of immunofluorescence; and (3) intranuclear particles resembling myxovirus nucleocapsids in the neurones and oligodendrocytes of the brain seen by electron microscopy. These observations were not concurrent, nor were they universal, but each was noted in several patients.

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References

  1. Connolly, T. H., Allen, I. V., Hurwitz, L. J., and Millar, J. H. D., Lancet, i, 542 (1967).

  2. Dayan, A. D., Gostling, J. V. T., Greaves, J. L., Stevens, D. W., and Woodhouse, M. A., Lancet, i, 980 (1967).

  3. Freeman, J. M., Magoffin, R. L., Lennette, E. H., and Herndon, R. M., Lancet, ii, 129 (1967).

  4. Katz, M., Rorke, L. B., Masland, W. S., Koprowski, H., and Tucker, S. H., New Engl. J. Med., 279, 793 (1968).

    Article  CAS  Google Scholar 

  5. Baublis, J. V., and Payne, F. E., Proc. Soc. Exp. Biol. and Med., 129, 593 (1968).

    Article  CAS  Google Scholar 

  6. Millonig, G., J. Appl. Phys., 32, 1637 (1961).

    Google Scholar 

  7. Millonig, G., J. Biophys. Biochem. Cytol., 11, 736 (1961).

    Article  CAS  Google Scholar 

  8. Tawara, J., Virology, 25, 322 (1965).

    Article  CAS  Google Scholar 

  9. Herndon, R. M., and Rubinstein, L. J., Neurology, 18, 8 (1968).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania

    MICHAEL KATZ

  2. Department of Pediatrics, University of Pennsylvania,

    MICHAEL KATZ

  3. Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania

    SHINSAKU OYANAGI & HILARY KOPROWSKI

Authors
  1. MICHAEL KATZ
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  2. SHINSAKU OYANAGI
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  3. HILARY KOPROWSKI
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KATZ, M., OYANAGI, S. & KOPROWSKI, H. Subacute Sclerosing Panencephalitis: Structures resembling Myxovirus Nucleocapsids in Cells cultured from Brains. Nature 222, 888–890 (1969). https://doi.org/10.1038/222888a0

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