Abstract
THE therapeutic effect of sodium magnesium-chlorophylliu in patients with herpes simplex and herpes zoster1 has aroused our interest in the mechanism of its viricidal activity. In the case of herpetic keratitis, locally applied sodium magnesium-chlorophyllin is as effective as kericid1 (Smith, Kline and French Ltd, iodoxuridine 0.1 per cent, thiomersal 0.002 per cent in distilled water). Sodium magnesium-chlorophyllin isolated from conifer needles is active against viruses of the herpes group, vaccinia virus and myxoviruses (influenza A2 virus and Newcastle disease virus). Unlike sodium magnesium-chlorophyllin and a derivative of sodium-chlorophyllin in which the molecule lacks the metal atom in the centre of the por-phyrin ring, sodium-chlorophyllin with a copper atom in the centre of the porphyrin ring has not shown viricidal activity2.
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References
Belenky, G. B., and Krikun, B. L., in Advances in Clinical and Experimental Medicine, 363 (in Russian) (Moscow, 1967).
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Vostrilova, N. V., thesis, Univ. Tashkent (in Russian) (1959).
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MEKLER, L., BYCHOVSKY, A. & KRIKUN, B. Electron Microscope Study of the Viricidal Properties of Sodium Magnesium-chlorophyllin. Nature 222, 574–575 (1969). https://doi.org/10.1038/222574b0
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DOI: https://doi.org/10.1038/222574b0
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