Abstract
THE chicken–embryo–lethal–orphan (CELO) virus, an endogenous adenovirus of chicken eggs and the aetiologic agent of an inapparent infection in chickens1–3, is oncogenic when inoculated subcutaneously in hamsters4,5. Although a number of other viruses have also been found to be tumorigenic, only the highly oncogenic simian virus 40 (SV40) and the adeno 7–SV40 hybrid have induced ependymomas in laboratory animals6–8. Because embryonated eggs are used in producing certain vaccines, the work described here was undertaken to determine the effect of inoculating CELO virus into the brains of newborn golden Syrian hamsters.
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MANCINI, L., YATES, V., JASTY, V. et al. Ependymomas induced in Hamsters inoculated with an Avian Adenovirus (CELO). Nature 222, 190–191 (1969). https://doi.org/10.1038/222190a0
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DOI: https://doi.org/10.1038/222190a0
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