Abstract
BECAUSE of its membranous nature, the greater omentum of the mouse is a convenient tissue for serial studies of the cellular events in an immune response. Using mice it was found that after intraperitoneal stimulation with sheep erythrocytes the number of milk spots on the omentum was markedly increased1. These milk spots represent accumulations of varying numbers of lymphoid cells and macrophages. By a modification of the local haemolysis in gel technique it was shown that large milk spots produced haemolytic antibodies against sheep erythrocytes1. After repeated stimulation, clusters of plasma cells could be identified in the vicinity of relatively large milk spots. In some experiments the omenta were explanted into tissue culture, and continued to produce antibody in vitro for more than 60 days2.
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KRÜSMANN, W., KASEMIR, H. & FISCHER, H. Thymus Dependent Mesothelial Proliferation after Antigenic Stimulation. Nature 222, 1195–1196 (1969). https://doi.org/10.1038/2221195a0
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DOI: https://doi.org/10.1038/2221195a0
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