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Immunoglobulin Lambda Chain Structure: Two Genes, One Polypeptide Chain

Abstract

The lambda chain seems to be encoded by two separate germ-line genes (a specificity region gene and a common region gene) which are expressed as a single, continuous polypeptide chain. Antibody light chains appear to be an exception to the rule of “one gene, one polypeptide chain”.

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HOOD, L., EIN, D. Immunoglobulin Lambda Chain Structure: Two Genes, One Polypeptide Chain. Nature 220, 764–767 (1968). https://doi.org/10.1038/220764a0

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