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Further Evidence for the Simultaneous Initiation of DNA Replication in both X Chromosomes of Bovine Female

Abstract

THE existence of differential rates of mammalian sex chromosome replication late in the DNA synthetic period has been well established1, but there is still controversy about the replicative behaviour of sex chromosomes at the beginning of the S period. Several reports suggest that, for a given complement, the sex chromosomes which synthesize their DNA at a higher rate at the end of the S period are late in initiating DNA synthesis2–9. But others suggest that both sex chromosomes begin replication almost simultaneously, even earlier than some autosomes10–13. This experiment was designed to investigate the replicative behaviour of the X chromosomes in the bovine (Bos taurus) female complement at various times during the DNA synthetic period with the hope of finding an explanation for the discrepancy. The chromosome complement of the cow is advantageous for this experiment, because the two X chromosomes are the only submetacentric ones and can easily be distinguished from the fifty-eight acrocentric autosomes.

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References

  1. Mukherjee, B. B., and Sinha, A. K., Canad. J. Genet. Cytol., 5, 490 (1963).

    Article  CAS  Google Scholar 

  2. Hsu, T. C., J. Cell Biol., 23, 53 (1964).

    Article  CAS  Google Scholar 

  3. Hsu, T. C., and Lockhart, I., Hereditas, 52, 320 (1965).

    Article  Google Scholar 

  4. Petersen, A. J., J. Cell Biol., 23, 651 (1964).

    Article  CAS  Google Scholar 

  5. Cave, M., Hereditas, 54, 338 (1966).

    Article  CAS  Google Scholar 

  6. Priest, J. H., Heady, J. E., and Priest, R. E., J. Cell Biol., 35, 483 (1967).

    Article  CAS  Google Scholar 

  7. Ockey, C. H., Wennstrom, J., and Chapelle, A. de la, Hereditas, 54, 277 (1966).

    Article  CAS  Google Scholar 

  8. Sofuni, T., and Sandberg, A. A., Cytogenetics, 6, 357 (1967).

    Article  CAS  Google Scholar 

  9. Schneider, L. K., and Rieke, W. O., J. Cell Biol., 33, 497 (1967).

    Article  CAS  Google Scholar 

  10. Mukherjee, B. B., Burkholder, G. D., Sinha, A. K., and Ghosal, S. K., Canad. J. Genet. Cytol., 8, 631 (1966).

    Article  CAS  Google Scholar 

  11. Mukherjee, B. B., Sinha, A. K., Mann, K. E., Ghosal, S. K., and Wright, W. C., Nature, 214, 710 (1967).

    Article  ADS  CAS  Google Scholar 

  12. Stubblefield, E., J. Cell Biol., 25, 137 (1965).

    Article  CAS  Google Scholar 

  13. Bianchi, N. O., and Bianchi, M. S. A. de, Chromosoma, 17, 273 (1965).

    Article  CAS  Google Scholar 

  14. Gilbert, C. W., Muldal, S., and Lajtha, L. G., Nature, 208, 159 (1965).

    Article  ADS  CAS  Google Scholar 

  15. Stone, G. E., Miller, O. L., and Prescott, D. M., J. Cell Biol., 25, 171 (1965).

    Article  CAS  Google Scholar 

  16. Leach, W. M., Exp. Cell Res., 35, 201 (1964).

    Article  CAS  Google Scholar 

Download references

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MUKHERJEE, B., WRIGHT, W., GHOSAL, S. et al. Further Evidence for the Simultaneous Initiation of DNA Replication in both X Chromosomes of Bovine Female. Nature 220, 714–716 (1968). https://doi.org/10.1038/220714a0

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