Abstract
The amino-acid polymerization factors S1 and S3 form complexes with most aminoacyl-tRNA species, including met-tRNAM, but not F-met-tRNAF and not met-tRNAF. This discrimination may be a basis for avoiding one kind of ambiguity in translation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Marcker, K. A., and Sanger, F., J. Mol. Biol., 8, 835 (1964).
Marcker, K. A., J. Mol. Biol., 14, 63 (1965).
Clark, B. F. C., and Marcker, K. A., J. Mol. Biol., 17, 394 (1966).
Adams, J. M., and Capecchi, M. R., Proc. US Nat. Acad. Sci., 55, 147 (1966).
Webster, R. E., Engelhardt, D. L., and Zinder, N. D., Proc. US Nat. Acad. Sci., 55, 155 (1966).
Capecchi, M. R., Proc. US Nat. Acad. Sci., 55, 1517 (1966).
Thach, R. E., Dewey, K. F., Brown, J. C., and Doty, P., Science, 153, 416 (1966).
Sundararajan, T., and Thach, R. E., J. Mol. Biol., 19, 74 (1966).
Salas, M., Hille, M. B., Last, J. A., Wahba, A. J., and Ochoa, S., Proc. US Nat. Acad. Sci., 57, 387 (1967).
Ghosh, H. P., Söll, D., and Khorana, H. G., J. Mol. Biol., 25, 275 (196
Lengyel, P., in Molecular Genetics, Part II (edit. by Taylor, J. H.), 194 (Academic Press, New York, 1967).
Marcker, K. A., Clark, B. F. C., and Anderson, J. S., Cold Spring Harbor Symp. Quant. Biol., 31, 279 (1966).
Skoultchi, A., Ono, Y., Moon, H. M., and Lengyel, P., Proc. US Nat. Acad. Sci., 60, 675 (1968).
Gordon, J., Proc. US Nat. Acad. Sci., 58, 1574 (1967).
Gordon, J., Proc. US Nat. Acad. Sci., 59, 179 (1968).
Allende, J. E., Seeds, N. W., Conway, T. W., and Weissbach, H., Proc. US Nat. Acad. Sci., 58, 1566 (1967).
Ertel, R., Brot, N., Redfield, B., Allende, J. E., and Weissbach, H., Proc. US Nat. Acad. Sci., 59, 861 (1968).
Ravel, J. M., Shorey, R. L., Froehner, S., and Shive, N., Arch. Biochem. Biophys., 125, 514 (1968).
Ravel, J. M., Proc. US Nat. Acad. Sci., 57, 1811 (1967).
Lucas-Lenard, J., and Haenni, A., Proc. US Nat. Acad. Sci., 59, 554 (1968).
Ono, Y., Skoultchi, A., Klein, A., and Lengyel, P., 156th ACS National Meeting Abstracts, Division of Biol. Chem., 239 (1968).
Sundharadas, G., Katze, J. R., Söll, D., Konigsberg, W., and Lengyel, P., Proc. US Nat. Acad. Sci., 61 (in the press).
Adams, J. M., J. Mol. Biol., 33, 571 (1968).
Dube, S. K., Marcker, K. A., Clark, B. F. C., and Cory, S., Nature, 218, 232 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ONO, Y., SKOULTCHI, A., KLEIN, A. et al. Peptide Chain Elongation: Discrimination against the Initiator Transfer RNA by Microbial Amino-acid Polymerization Factors. Nature 220, 1304–1307 (1968). https://doi.org/10.1038/2201304a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2201304a0
This article is cited by
-
Properties and regulation of the GTPase activities of elongation factors Tu and G, and of initiation factor 2
Molecular and Cellular Biochemistry (1981)
-
Discrimination between eukaryotic and prokaryotic, and formylated and non-formylated, initiator tRNAs by eukaryotic initiation factor EIF-3
Nature (1975)
-
Interaction between Guanosine Derivatives and Factors involved in the Initiation of Protein Synthesis
Nature (1970)
-
The S1 Factor in Peptide Chain Elongation
Nature (1970)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
