Abstract
VARIOUS contrasting data have been published concerning the incidence of glucose-6-phosphate dehydrogenase deficiency in subjects with normal and abnormal haemoglobins (reviewed in ref. 1). We have collected data on the distribution of genetic variants of glucose-6-phosphate dehydrogenase in the erythrocytes of 1,451 normal male subjects living in western Nigeria, most of them Yoruba (estimated more than 90 per cent). Three common variants are encountered in this population, two of them with normal activity, A and B, and one associated with enzyme deficiency, A− (according to the nomenclature recommended by the World Health Organization2). The incidences of these variants in normal Kigerian males are approximately 21, 57 and 22 per cent respectively3–5. Rare variants have also been described6.
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References
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LUZZATTO, L., ALLAN, N. Relationship between the Genes for Glucose-6-phosphate Dehydrogenase and for Haemoglobin in a Nigerian Population. Nature 219, 1041–1042 (1968). https://doi.org/10.1038/2191041a0
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DOI: https://doi.org/10.1038/2191041a0
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