Abstract
INVESTIGATIONS are now in progress in this laboratory to elucidate the mechanism of tumour formation induced by the Schmidt–Ruppin strain of RSV (supplied by Dr Robert Holdenried, National Cancer Institute, National Institutes of Health, Bethesda, Maryland) in baboons (Papio sp.)1. To enhance the oncogenic potential of the virus a number of animals were placed on a regimen of celestone (B-methazone-21-phosphate) throughout the experiment at a dose of 3 mg/kg/day (supplied by the Schering Corporation, Bloomfield, New Jersey). For control purposes, animals of similar age were placed on this cortisone regimen but were not inoculated with RSV. This report is concerned with development of a tumour and subsequent death of an immature baboon treated with cortisone but not inoculated with RSV. This animal was maintained, however, in the same rooms with the other baboons which developed tumours as a result of inoculation with RSV.
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KALTER, S., EUGSTER, A., VICE, T. et al. Rous Sarcoma in Baboons: Development of Tumour in an Uninoculated Animal treated with Cortisone. Nature 218, 884 (1968). https://doi.org/10.1038/218884a0
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DOI: https://doi.org/10.1038/218884a0
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