Abstract
Fibrinogen from a patient with a blood coagulation disorder has an amino-acid substitution (arginine to serine) in the vicinity of the bond split by thrombin during normal blood coagulation.
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References
Imperato, C., and Dettori, A. G., Helv. Paediat. Acta, 13, 380 (1958).
Menaché, D., Thromb. Diath. Haemorrh., 10, Suppl. 13, 173 (1964).
Hasselback, R., Marion, R. B., and Thomas, J. W., Canad. Med. Assoc. J., 88, 19 (1963).
Beck, E. A., Blood, 24, 853 (1964).
Beck, E. A., Charache, P., and Jackson, D. P., Nature, 208, 143 (1965).
Von Felten, A., Duckert, F., and Frick, P., Schweiz. Med. Wochschr., 95, 1453 (1965).
Forman, W. B., Boyer, M. H., and Ratnoff, O. D., Tenth Annual Meeting, Amer. Soc. Hematology, Toronto (1967).
Mammen, E. F., Prasad, A. S., and Au, C. C., Proc. Sixteenth Annual Symposium on Blood. Wayne State University, School of Medicine (1968).
Cohn, E. J., Strong, L. E., Hughes, jun., W. L., Mulford, D. J., Ashworth, J. N., Melin, M., and Taylor, H. L., J. Amer. Chem. Soc., 68, 459 (1946).
Laki, K., Arch. Biochem. Biophys., 32, 317 (1951).
Blombäck, M., Arkiv Kemi, 12, 387 (1958).
Blombäck, B., Arkiv Kemi, 12, 99 (1958).
Blombäck, B., Blombäck, M., Hessel, B., and Iwanaga, S., Nature, 215, 1445 (1967).
Miller, K. D., and Copeland, W. H., Exp. Mol. Pathol., 4, 431 (1965).
Blombäck, B., Blombäck, M., Edman, P., and Hessel, B., Biochim. Biophys. Acta, 115, 371 (1966).
Shainoff, J. R., and Page, I. H., Circulation Res., 8, 1013 (1960).
Iwanaga, S., Wallén, P., Gröndahl, N. J., Henschen, A., and Blombäck, B., Biochim. Biophys. Acta, 147, 606 (1967).
Nirenberg, M., Leder, P., Bernfield, M., Brimacombe, R., Trupin, J., Rottman, F., and O'Neal, C., Proc. US Nat. Acad. Sci., 53, 1161 (1965).
Iwanaga, S., Henschen, A., and Blombäck, B., Acta Chem. Scand., 20, 1183 (1966).
Levy, A. L., and Chung, D., Anal. Chem., 25, 396 (1953).
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BLOMBÄCK, M., BLOMBÄCK, B., MAMMEN, E. et al. Fibrinogen Detroit—a Molecular Defect in the N-terminal Disulphide Knot of Human Fibrinogen?. Nature 218, 134–137 (1968). https://doi.org/10.1038/218134a0
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DOI: https://doi.org/10.1038/218134a0
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