Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

New Enzymatic Route for the Inactivation of Angiotensin

Abstract

Experiments show that swine kidney and human urine contain a new angiotensinase that breaks the prolylphenylalanine bond In various peptides. The product of this enzymatic hydrolysis—the N-terminal heptapeptide sequence of angiotensin—is biologically inactive.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Erdös, E. G., and Yang, H. Y. T., in Hypotensive Peptides (edit. by Erdös, E. G., Back, N., and Sicuteri, F.), 235 (Springer–Verlag, New York, 1966)

    Google Scholar 

  2. Khairallah, P. A., and Page, I. H., Biochem. Med., 1, 1 (1967).

    Article  CAS  Google Scholar 

  3. Moore, S., and Stein, W. H., J. Biol. Chem., 211, 907 (1954).

    CAS  PubMed  Google Scholar 

  4. Erdös, E. G., Sloan, E. M., and Wohler, I. M., Biochem. Pharmacol., 13, 893 (1964).

    Article  Google Scholar 

  5. Hodge, R. L., Ng, K. K. F., and Vane, J. R., Nature, 215, 138 (1967).

    Article  ADS  CAS  Google Scholar 

  6. Erdös, E. G., in Metabolic Factors Controlling Duration of Drug Action (edit. by Brodie, B. B., and Erdös, E. G.), 159 (Pergamon, Oxford, 1962).

    Google Scholar 

  7. Khairallah, P. A., Bumpus, F. M., Page, I. H., and Smeby, R. R., Science, 140, 672 (1963).

    Article  ADS  CAS  Google Scholar 

  8. Klaus, D., Kaffarnik, H., and Pfeil, H., Klin. Wschr., 41, 376 (1963).

    Article  CAS  Google Scholar 

  9. Nagatsu, I., Gillespie, L., Folk, J. E., and Glenner, G. G., Biochem. Pharmacol., 14, 721 (1965).

    Article  CAS  Google Scholar 

  10. Regoli, D., Riniker, B., and Brunner, H., Biochem. Pharmacol., 12, 637 (1963).

    Article  CAS  Google Scholar 

  11. Riniker, B., Metabolism, 13, 283 (1964).

    Google Scholar 

  12. Schröder, E., and Lübke, K., The Peptides, 2, 56 (Academic Press, New York, 1966).

    Google Scholar 

  13. Pickens, P. T., Bumpus, F. M., Lloyd, A. M., Smeby, R. R., and Page, I. H., Circulation Res., 17, 438 (1965).

    Article  CAS  Google Scholar 

  14. Zuber, H., Nature, 201, 613 (1964).

    Article  ADS  CAS  Google Scholar 

  15. Greenbaum, L. M., and Sherman, R., J. Biol. Chem., 237, 1082 (1962).

    CAS  PubMed  Google Scholar 

  16. Greenbaum, L. M., and Yamafuji, K., Life Sci., 4, 657 (1965).

    Article  CAS  Google Scholar 

  17. Dannenbergy, jun., A. M., and Smith, E. L., J. Biol. Chem., 215, 55 (1955).

    Google Scholar 

  18. Fruton, J. S., Irving, jun., G. W., and Bergmann, M., J. Biol. Chem., 141, 763 (1941).

    CAS  Google Scholar 

  19. Hanson, H., in Handbuch der Physiologisch-und Pathologisch-Chemischen Analyse (edit. by Lang, K., and Lehnartz, E.), Enzyme Teil C, 1 (Springer–Verlag, Heidelberg, 1966).

    Google Scholar 

  20. Ambler, R. P., in Methods in Enzymology (edit. by Hirs, C. H. W.), 11, 436 (Academic Press, New York, 1967).

    Google Scholar 

  21. Hartley, B. S., Ann. Rev. Biochem., 29, 45 (1960).

    Article  CAS  Google Scholar 

  22. Dannenberg, jun., A. M., and Smith, E. L., J. Biol. Chem., 215, 45 (1955).

    CAS  PubMed  Google Scholar 

  23. Erdös, E. G., Adv. Pharmacol. 4, 1 (1966).

    Article  Google Scholar 

  24. Erdös, E. G., and Yang, H. Y. T., Life Sci., 6, 569 (1967).

    Article  Google Scholar 

  25. Yang, H. Y. T., and Erdös, E. G., Nature, 215, 1402 (1967).

    Article  ADS  CAS  Google Scholar 

  26. Stewart, J. M., and Woolley, D. W., Nature, 207, 1160 (1965).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

YANG, H., ERDÖS, E. & CHIANG, T. New Enzymatic Route for the Inactivation of Angiotensin. Nature 218, 1224–1226 (1968). https://doi.org/10.1038/2181224a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2181224a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing