Abstract
CHOLERA exotoxin causes fluid production by the intestine when instilled into jejunal or ileal loops of anaesthetized rabbits1–3. Profuse quantities of isotonic fluid are produced by the small intestine without histological alteration of the mucosa4. The pathogenesis of the increased fluid production by the intestine in cholera is unsettled. It has not been determined whether the fluid production is the result of increased intestinal secretion, decreased intestinal absorption or a combination of these two factors. To assess the importance of altered intestinal absorption, absorption of d-glucose by the rabbit jejunum was measured both in the presence and absence of cholera diarrhoea.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
De, S. N., Nature, 183, 1533 (1959).
Norris, H. T., Schultz, S. G., and Curran, P. F., J. Infect. Dis., 117, 193 (1967).
Leitch, G. J., Burrows, W., and Stolle, C., J. Infect. Dis., 117, 197 (1967).
Elliott, H. L., and Yardley, J. H., Symposium on Cholera (US–Japan Co-operative Med. Science Program, California July 1967).
Cocco, A. E., Salem, A. A., and Hendrix, T. R., Bull. Johns Hopkins Hospital, 117, 1 (1965).
Finkelstein, R. A., Atthasanpunna, P., Chalusmaya, N., and Charunmethee, P., J. Immunol., 96, 440 (1966).
Scheff, M. F., and Smyth, D. H., J. Physiol., 128, 67P (1955).
Hoffman, W. S., J. Biol. Chem., 120, 51 (1937).
Schedl, H. P., and Clifton, J. A., Gastroenterology, 41, 492 (1961).
Cohnheim, J., translation by McKee, A. B., New Sydenham Soc., London, 3, 941 (1890).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SEREBRO, H., BAYLESS, T., HENDRIX, T. et al. Absorption of d-Glucose by the Rabbit Jejunum during Cholera Toxin-induced Diarrhoea. Nature 217, 1272–1273 (1968). https://doi.org/10.1038/2171272a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2171272a0
This article is cited by
-
Effect of glucose on jejunal water and solute absorption in the presence of glycodeoxycholate and oleate in man
Digestive Diseases and Sciences (1981)
-
Normal sugar uptakein vitro by small-bowel biopsies from a patient with cholera
The American Journal of Digestive Diseases (1977)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
