Abstract
THE general structural features of the various types of immunoglobulins are known and the details of the primary structure are gradually being filled in. A characteristic feature of the immune response, however, is its specificity and here the data have not been sufficient to reveal the structural basis of the specificity and even less the underlying genetic mechanism. The aim of the present investigation was to throw more light on this problem, and to this end we have determined the NH2-terminal sequences of a large number of χ-chains and made a comparison of their structures.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gelotte, B., Flodin, P., and Killander, J., Arch. Biochem. Biophys., suppl. 1, 319 (1962).
Fahey, J. L., and Horbett, A. P., J. Biol. Chem., 234, 2645 (1959).
Fleischman, J. B., Pain, R. H., and Porter, R. R., Arch. Biochem. Biophys., suppl. 1, 174 (1962).
Cohen, S., and Gordon, S., Biochem. J., 97, 460 (1965).
Fahey, J. L., and McLaughlin, C., J. Immunol., 91, 484 (1963).
Edman, P., and Begg, G., European J. Biochem., 1, 80 (1967).
Gray, W. R., Dreyer, W. J., and Hood, L., Science, 155, 465 (1967).
Putnam, F. W., Titani, K., and Whitley, E., Proc. Roy. Soc., B, 166, 124 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
NIALL, H., EDMAN, P. Two Structurally Distinct Classes of Kappa-chains in Human Immunoglobulins. Nature 216, 262–263 (1967). https://doi.org/10.1038/216262a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/216262a0
This article is cited by
-
Antibody diversity: Can more than one gene encode each variable region?
Immunogenetics (1974)
-
Distribution of an Idiotypic Determinant of Human Light Chains in the Immunoglobulins of Normal Individuals
Nature New Biology (1973)
-
Isotypes in Human Immunoglobulin λ-Chains
Nature New Biology (1971)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.