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Inhibition of DNA-dependent RNA Polymerase by 4-Nitroquinoline-N-oxide in Isolated Nuclei

Nature volume 215, pages 749–750 (1967)Cite this article

Abstract

4-NITROQUINOLINE-N-OXIDE (4-NQO) is a potent carcinogen1 and mutagen2, which has been shown to induce tumours in mammals3, cause nuclear abnormalities in Tetrahymena4 and induce alterations in tissue culture cell nuclei5.

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Authors and Affiliations

  1. University of Texas, Southwestern Medical School, Department of Pathology, Laboratories for Cell Research, Woodlawn Hospital, Dallas, Texas

    J. S. PAUL, R. C. REYNOLDS & P. O'B. MONTGOMERY jun.

Authors
  1. J. S. PAUL
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  2. R. C. REYNOLDS
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  3. P. O'B. MONTGOMERY jun.
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PAUL, J., REYNOLDS, R. & MONTGOMERY, P. Inhibition of DNA-dependent RNA Polymerase by 4-Nitroquinoline-N-oxide in Isolated Nuclei. Nature 215, 749–750 (1967). https://doi.org/10.1038/215749a0

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