Abstract
IN recent years, Wagner1 and Selikoff et al.2 have shown that a rare tumour, the diffuse mesothelioma of the pleura and peritoneum, is associated with past exposure to asbestos. It appears that the amount of asbestos required to produce these tumours is small and that the latent period is very long. The connexion between exposure to asbestos and the production of mesotheliomas is being studied in a number of laboratories, and the possibility that trace metal constituents or contaminating oils may have a role has been suggested3. As yet, little is known about the fate of inhaled asbestos fibres and in particular about their movement out of the lung into other organs. The experiment described here was planned to assess the possibility of using radioactivity, induced in asbestos fibres by neutron irradiation, to trace their translocation in rats after administration by intrapleural injection.
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References
Wagner, J. C., Sleggs, C. A., and Marchand, P., Brit. J. Indust. Med., 17, 260 (1960).
Selikoff, I. J., Churg, J., and Hammond, E. C., J. Amer. Med. Ass., 188, 22 (1964).
Harington, J. S., and Roe, F. J. C., Ann. NY Acad. Sci., 132, 439 (1965).
Wagner, J. C., Proc. Quadrennial International Conference on Cancer, Perugia (1965).
Howells, G. R., Wright, C. F., and Harrison, G. E., J. Animal Technicians. Ass., 14, 1 (1964).
Salmon, L., Proc. IAEA Symposium on Radiochemical Methods of Analysis, Salzburg (1965).
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HOLMES, A., MORGAN, A. Leaching of Constituents of Chrysotile Asbestos in vivo. Nature 215, 441–442 (1967). https://doi.org/10.1038/215441b0
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DOI: https://doi.org/10.1038/215441b0
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Journal of Radioanalytical Chemistry (1968)
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