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Influence of Denervation on Localization of Neurotoxins from Clapid Venoms in Rat Diaphragm

Nature volume 215, pages 1177–1178 (1967)Cite this article

Abstract

α-BUNGAROTOXIN1,2 isolated from the venom of Bungarus multicinctus, as well as cobra neurotoxin3,4 from the venom of Naja naja atra, has been found to block neuromuscular transmission by an antidepolarizing action similar to that of d-tubocurarine. These conclusions have been further supported by the autoradiographic findings that α-bungarotoxin labelled with iodine-131 (ref. 5), as well as cobra neurotoxin6, accumulates on the motor end-plate zone of the mouse diaphragm in the same way as d-tubocurarine7

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References

  1. Chang, C. C., and Lee, C. Y., Arch. Intern. Pharmacodyn. Ther., 144, 241 (1963).

    CAS  Google Scholar 

  2. Lee, C. Y., and Chang, C. C., Intern. Symp. Animal Venoms, São Paulo, Brazil (1966).

  3. Su, C., Chang, C. C., and Lee, C. Y., Animal Toxins, 259 (Pergamon Press, Oxford and New York, 1966).

  4. Chang, C. C., and Lee, C. Y., Brit. J. Pharmacol. Chemother., 28, 172 (1966).

    Article  CAS  Google Scholar 

  5. Lee, C. Y., and Tseng, L. F., Toxicon, 3, 281 (1966).

    Article  CAS  Google Scholar 

  6. Lee, C. Y., Tseng, L. F., and Chiu, T. H., Seventh Intern. Cong. Biochem., Tokyo (1967).

  7. Waser, P. G., and Lüthi, U., Arch. Intern. Pharmacodyn. Ther., 112, 272 (1957).

    CAS  Google Scholar 

  8. Waser, P. G., J. Pharm. Pharmacol., 12, 577 (1966).

    Article  Google Scholar 

  9. Axelsson, J., and Thesleff, S., J. Physiol., 147, 178 (1959).

    Article  CAS  Google Scholar 

  10. Miledi, R., J. Physiol., 151, 1 (1960).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

    C. Y. LEE, L. F. TSENG & T. H. CHIU

Authors
  1. C. Y. LEE
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  2. L. F. TSENG
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  3. T. H. CHIU
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LEE, C., TSENG, L. & CHIU, T. Influence of Denervation on Localization of Neurotoxins from Clapid Venoms in Rat Diaphragm. Nature 215, 1177–1178 (1967). https://doi.org/10.1038/2151177a0

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