Abstract
THERE is still disagreement about whether reticulo-endothelial function depends on a serum factor1–3. There is substantial evidence that in certain mammals, especially the rat, “reticulo-endothelial phagocytosis” requires the participation of a serum factor for certain colloids. In this species, blockade of the reticulo-endothelial system can be attributed to depletion of a serum factor, perhaps antibody or a complement component. By contrast, in the rabbit, reticulo-endothelial blockade can occur independent of serum factors4, and experimental agammaglobulinaemia in the chicken is not associated with any deficiency of reticulo-endothelial clearance in vivo5. Until now, however, no critical evidence has been presented about the exact nature of the serum factor operating in the rat system or the nature of the blockade in animals not requiring the serum factor.
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JEUNET, F., SHOEMAKER, W. & GOOD, R. Isolated Double Perfusion of the Liver in the Study of the Reticulo-endothelial System. Nature 215, 61–62 (1967). https://doi.org/10.1038/215061a0
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DOI: https://doi.org/10.1038/215061a0
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