Abstract
ANTIBODY, by virtue of its specificity, can be a valuable tool for identifying structures visible in the electron microscope. It is often not necessary to bind the antibody to an electron-dense label because antibody molecules are so large that they can readily be distinguished under the electron microscope by the negative staining technique, particularly when they have combined with a small particulate or filamentous antigen as, for example, with virus particles1,2 or flagella3.
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References
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LAWN, A. Simple Immunological Labelling Method for Electron Microscopy and its Application to the Study of Filamentous Appendages of Bacteria. Nature 214, 1151–1152 (1967). https://doi.org/10.1038/2141151a0
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DOI: https://doi.org/10.1038/2141151a0
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