Abstract
INVESTIGATIONS of the pattern of DNA replication have shown that the X chromosomes in normal female cells exhibit marked asynchrony and one of them has a pronounced pattern of late replication. Other chromosomes differ also with respect to the time of DNA synthesis. In male cells it has been found that the Y chromosome replicates late compared with chromosomes of the 21–22 group1,2. This relatively late replication pattern of the Y chromosome has also been found in other mammals3–5. Investigations in patients with additional X chromosomes have shown that all X chromosomes in excess of one have pronounced late replicating patterns, similar to that of one of the X chromosomes in normal female cells6–10. As far as we know there have been only two previous references to the replication pattern of cells with two Y chromosomes. The presence of two heavily labelled presumptive Y chromosomes in an XYY male was quoted as a personal communication from Castilla, Breg and Miller, in the review by Miller11. Kikuchi and Sandberg12 studied replication patterns in two males with XYY karyotype.
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BOCZKOWSKI, K., CASEY, M. Pattern of DNA Replication of the Sex Chromosomes in Three Males, Two with XYY and One with XXYY Karyotype. Nature 213, 928–930 (1967). https://doi.org/10.1038/213928a0
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DOI: https://doi.org/10.1038/213928a0
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