Abstract
RECENT reports that epinephrine and glucagon, hormones which affect the generation of cyclic 3′,5′-AMP, also influence the release of pancreatic insulin1–5 have led us to examine the effect of this cyclic nucleotide on insulin secretion. In the present experiments the effects on insulin secretion of theophylline, a methyl xanthine derivative which inhibits cyclic nucleotide phosphodiesterase6 and increases the intracellular steady state level of cyclic 3′,5′-AMP, alone and in combination with epinephrine and alpha and beta adrenergic blocking agents, have been examined in the rat.
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TURTLE, J., LITTLETON, G. & KIPNIS, D. Stimulation of Insulin Secretion by Theophylline. Nature 213, 727–728 (1967). https://doi.org/10.1038/213727a0
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DOI: https://doi.org/10.1038/213727a0
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