Abstract
THE serum of many conventional and so-called germ-free animals contains bactericidal activity against certain Gram-negative bacteria1. This activity is effective against those bacteria commonly found in the intestinal tract or bacteria related to them. Even the feeding of heat-killed bacteria to germ-free chicks results in specific agglutinin2. Thus it appears that antigens from the lumen of the gut may become transported to sites of antibody synthesis. It is well established that gamma globulin and possibly other serum globulins are decreased in germ-free animals3–5. All immunoglobulins were markedly decreased in the germ-free mouse6.
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PHILLIPS, A., LACHAPELLE, R. Serum Proteins in the Germ-free Mouse after Oral Challenge with Candida albicans. Nature 213, 709–710 (1967). https://doi.org/10.1038/213709a0
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DOI: https://doi.org/10.1038/213709a0
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