Abstract
WE have found that a non-steroidal oestrogen antagonist1 will inhibit spontaneous (4 µg/ml.) and electrically induced (20 µg/ml.) contractions of the oestrous rat uterus in vitro1,2. Similar results were obtained in vitro with electrically stimulated uteri (about 30 µg/ml.) removed from rabbits immediately after coitus. This report concerns the effect of CN-55,945-27* on uterine contractility when infused intravenously into unanaesthetized rabbits post partum.
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References
Callantine, M. R., Humphrey, R. R., Lee, S. L., Windsor, B. L., Schottin, N. H., and O'Brien, O. P., Fed. Proc., 25, 190 (1966).
Callantine, M. R., Humphrey, R. R., Lee, S. L., Windsor, B. L., Schottin, N. H., and O'Brien, O. P., Endocrinology, 79, 153 (1966).
Bass, P., and Callantine, M. R., Nature, 203, 1367 (1964).
Csapo, A. I., and Takeda, H., Amer. J. Obstet. and Gynec., 91, 221 (1965).
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CALLANTINE, M., PATRICK O'BRIEN, O., WINDSOR, B. et al. Inhibition of Uterine Contractions in vivo in the Unanaesthetized Rabbit. Nature 213, 507–508 (1967). https://doi.org/10.1038/213507a0
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DOI: https://doi.org/10.1038/213507a0
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