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Inhibition of Uterine Contractions in vivo in the Unanaesthetized Rabbit

Abstract

WE have found that a non-steroidal oestrogen antagonist1 will inhibit spontaneous (4 µg/ml.) and electrically induced (20 µg/ml.) contractions of the oestrous rat uterus in vitro1,2. Similar results were obtained in vitro with electrically stimulated uteri (about 30 µg/ml.) removed from rabbits immediately after coitus. This report concerns the effect of CN-55,945-27* on uterine contractility when infused intravenously into unanaesthetized rabbits post partum.

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References

  1. Callantine, M. R., Humphrey, R. R., Lee, S. L., Windsor, B. L., Schottin, N. H., and O'Brien, O. P., Fed. Proc., 25, 190 (1966).

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  2. Callantine, M. R., Humphrey, R. R., Lee, S. L., Windsor, B. L., Schottin, N. H., and O'Brien, O. P., Endocrinology, 79, 153 (1966).

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CALLANTINE, M., PATRICK O'BRIEN, O., WINDSOR, B. et al. Inhibition of Uterine Contractions in vivo in the Unanaesthetized Rabbit. Nature 213, 507–508 (1967). https://doi.org/10.1038/213507a0

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