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Effect on the Infectivity of Various Viruses by the Intestinal Factor of Normal Mice which inactivates Murine Hepatitis Virus

Nature volume 213, pages 293–294 (1967)Cite this article

Abstract

THE capability of the intestine of normal mice to inactivate murine hepatitis virus (MHV-3) (ref. 1) has been reported2. The inactivating factor is present mainly in the first section of the mucosa of the small intestine of the adult mouse3; it is present in the intestine of germ-free mice4, and its interaction with the virus in vitro is dependent on temperature and incubation time3. The factor is inactivated at 70° C for 10 min, is not dialysable and is not present in acetone-dried powders of mouse intestine5. The present paper deals with the effect of the partially purified inhibiting factor on the infectivity of several viruses.

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References

  1. Dick, G. W. A., Niven, J. S. F., and Gledhill, A. W., Brit. J. Exp. Path., 37, 90 (1956).

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  2. Piazza, M., Nature, 203, 1196 (1964).

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Authors and Affiliations

  1. Institute of Infectious Diseases, University of Naples, Via Cotugno 1

    M. PIAZZA & G. PANE

  2. Istituto Sieroterapico Italiano, Via S. Giacomo dei Capri 66, Naples

    L. PICCIOTTO & D. LOMBARDI

Authors
  1. M. PIAZZA
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  2. G. PANE
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  3. L. PICCIOTTO
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  4. D. LOMBARDI
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PIAZZA, M., PANE, G., PICCIOTTO, L. et al. Effect on the Infectivity of Various Viruses by the Intestinal Factor of Normal Mice which inactivates Murine Hepatitis Virus. Nature 213, 293–294 (1967). https://doi.org/10.1038/213293a0

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