Abstract
A LONG standing problem in mitochondrial metabolism is the origin of the inhibition of oxidation of anionic substrates which sets in on adding an excess of any agent which uncouples oxidative phosphorylation. It has been noted that the inhibition is moved to higher uncoupler concentrations when the substrate concentration is raised1. This suggests that for some reason the permeation of substrate fails to keep up with the metabolic demand in presence of excess uncoupler. This supposition accords with observations that the respiratory carriers are left in an oxidized condition when inhibition supervenes2.
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References
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HARRIS, E., VAN DAM, K. & PRESSMAN, B. Dependence of Uptake of Succinate by Mitochondria on Energy and its Relation to Potassium Retention. Nature 213, 1126–1127 (1967). https://doi.org/10.1038/2131126a0
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DOI: https://doi.org/10.1038/2131126a0
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