Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Action of Atomic Hydrogen on Ribonuclease in Aqueous Solution

Abstract

Atomic hydrogen seems to react with ribonuclease in aqueous solution, not by attacking the molecule at random, but by reacting with specific amino-acids in the enzyme. It seems to have a special affinity for aromatic and sulphur-containing amino-acids, even though these may be some way from the surface of the enzyme.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Navon, G., and Stein, G., J. Phys. Chem., 69, 1384, 1389 (1965) and references therein.

    Article  CAS  Google Scholar 

  2. Navon, G., and Stein, G., Israel J. Chem., 2, 151 (1964).

    Article  CAS  Google Scholar 

  3. Mee, L. K., Navon, G., and Stein, G., Nature, 204, 1056 (1964).

    Article  ADS  CAS  Google Scholar 

  4. Czapski, G., Frohwirth, N., and Stein, G., Nature, 207, 1191 (1965).

    Article  ADS  CAS  Google Scholar 

  5. Czapski, G., and Stein, G., Israel J. Chem., 2, 15 (1964).

    Article  CAS  Google Scholar 

  6. Czapski, G., and Stein, G., J. Phys. Chem., 64, 219 (1960).

    Article  CAS  Google Scholar 

  7. Navon, G., and Stein, G., J. Phys. Chem., 70, 3630 (1966).

    Article  CAS  Google Scholar 

  8. Mee, L. K., Navon, G., Stein, G., Biochim. Biophys. Acta, 104, 151 (1965).

    Article  CAS  Google Scholar 

  9. Anfinsen, C. B., Redfield, R. R., Choate, W. L., Page, J., and Carroll, W. R., J. Biol. Chem., 207, 201 (1954).

    CAS  Google Scholar 

  10. Ellman, G. L., Arch. Biochem. Biophys., 82, 70 (1959).

    Article  CAS  Google Scholar 

  11. Scheraga, H. A., and Rupley, J. A., Adv. Enzymol., 24, 161 (1962).

    CAS  Google Scholar 

  12. Braams, E., in Pulse Radiolysis, 171 (Academic Press, New York, 1965); Radiat. Res., 27, 319 (1966).

    Google Scholar 

  13. Smith, T. W., and Adelstein, S. J., Radiat. Res., 24, 119 (1965).

    Article  ADS  CAS  Google Scholar 

  14. Mee, L. K., Radiat. Res., 21, 501 (1964).

    Article  ADS  CAS  Google Scholar 

  15. Anfinsen, C. B., J. Polymer Sci., 49, 31 (1961); White, F. H., jun., J. Biol. Chem., 236, 1353 (1961).

    Article  ADS  CAS  Google Scholar 

  16. Stein, G., Princeton Univ. Conf. Chemistry of Sulfides, June, 1966.

  17. Stein, G., and Stiassny, G., Nature, 176, 734 (1955); Stein, G., and Swallow, A. J., J. Chem. Soc., 306 (1958); Paiss, Y., and Stein, G., J. Chem. Soc., 2905 (1958).

    Article  ADS  CAS  Google Scholar 

  18. Smyth, D. G., Stein, W. H., and Moore, S., J. Biol. Chem., 238, 227 (1963); Stein, W. H., Israel J. Med. Sci., 1, 1229 (1965).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

HOLMES, B., NAVON, G. & STEIN, G. Action of Atomic Hydrogen on Ribonuclease in Aqueous Solution. Nature 213, 1087–1091 (1967). https://doi.org/10.1038/2131087a0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2131087a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing