Abstract
IT is well established that hypertonic urine is produced in. the kidney by means of a countercurrent multiplier system and that the formation of such urine requires a hyper-osmotic medullary interstitium. It is accepted that anti-diuretic hormone regulates the osmolality of the urine so produced by altering the permeability characteristics of" the distal areas of the nephron.
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MALVIN, R., FUSCO, M. Alterations in the Countercurrent Gradient by Lesions in the Median Eminence. Nature 212, 1591–1592 (1966). https://doi.org/10.1038/2121591a0
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DOI: https://doi.org/10.1038/2121591a0
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