Abstract
APPRECIABLE numbers of lymphocyte-like cells are found in the bone marrow of mice1,2 and other mammals3,4. Their origin has intrigued investigators for many years3. Yoffey3,4 considers that these cells have a haematogeneous origin, while Osmond and Everett5 find no evidence for the influx into the bone marrow of large numbers of blood lymphocytes. Evidence is accumulating that mitochon-drial content is a useful criterion for characterization of lymphocytes6–9 and that electron microscopy may help to elucidate the origin of some lymphocyte-like cells8. The present investigation was undertaken to compare the number of mitochondria in lymphocytes from blood and lymphocyte-like cells in bone marrow and to examine the ultrastructure of the latter.
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ALBERT, S., WOLF, P. & POTTER, R. Observations on the Origin of Lymphocyte-like Cells in Mouse Bone Marrow. Nature 212, 1577–1579 (1966). https://doi.org/10.1038/2121577a0
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DOI: https://doi.org/10.1038/2121577a0
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